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合成及含有咪唑并[4,5-d][1,2,6]噁二嗪环系的空前环扩核苷（RENs）的生物评价。

Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system.

机构信息

Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131, Napoli, Italy.

出版信息

Chem Commun (Camb). 2012 Sep 25;48(74):9310-2. doi: 10.1039/c2cc33511e. Epub 2012 Aug 9.

DOI:10.1039/c2cc33511e
PMID:22874871
Abstract

A small collection of ring-expanded nucleosides (RENs), containing the unprecedented bis-alkylated imidazo[4,5-d][1,2,6]oxadiazepine heterocyclic ring system, has been synthesized through a new general approach. Results of preliminary cytotoxicity tests on breast (MCF-7) and lung (A549) cancer cell lines are also reported.

摘要

已通过一种新的通用方法合成了一小部分环扩核苷（REN），其中包含前所未有的双烷基化咪唑[4,5-d][1,2,6]恶二嗪杂环系统。还报告了初步的细胞毒性测试结果，这些测试针对乳腺癌（MCF-7）和肺癌（A549）癌细胞系。

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