School of Biological and Agricultural Engineering, Jilin University, Changchun 130022, Jilin Province, PR China.
Food Chem Toxicol. 2012 Oct;50(10):3814-8. doi: 10.1016/j.fct.2012.07.046. Epub 2012 Aug 1.
The aim of this thesis is to explore antioxidant activity of total flavonoids extracted from indocalamus leaves.
Aging mice model was established by D-galactose induction. Three groups of mice were treated with total flavonoids extracted from indocalamus leaves at doses of 20, 40 and 80 mg/kg d bw respectively. The antioxidant status in the aging mice was measured by determining the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and total anti-oxidant capability (T-AOC) in the serum and liver and malondialdehyde (MDA) content in the serum, liver and brain.
Compared with control group, extracts of indocalamus leaves significantly enhanced activities of SOD, GSH-Px, CAT in the serum and liver, and decreased MDA content in the serum, liver and brain at the tested doses.
Total flavonoids extracted from indocalamus leaves demonstrated the potent antioxidant activity.
本论文旨在探讨从淡竹叶中提取的总黄酮的抗氧化活性。
采用 D-半乳糖诱导法建立衰老小鼠模型。将三组小鼠分别用 20、40 和 80mg/kg 体重的淡竹叶总黄酮处理。通过测定血清和肝脏中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、过氧化氢酶（CAT）和总抗氧化能力（T-AOC）的活性以及血清、肝脏和大脑中丙二醛（MDA）的含量来检测衰老小鼠的抗氧化状态。
与对照组相比，在测试剂量下，淡竹叶提取物显著提高了血清和肝脏中 SOD、GSH-Px、CAT 的活性，并降低了血清、肝脏和大脑中 MDA 的含量。
从淡竹叶中提取的总黄酮具有较强的抗氧化活性。
