[窄叶岩黄芪水提取物对D-半乳糖致亚急性衰老小鼠氧自由基代谢的影响]
[Effects of aqueous extract of Hedysarum austrosibiricum on metabolism of oxyen free radicals in subacute aging mice caused by D-galactose].
作者信息
Hailiqian Taoerdahong, Kang Jin-sen, Sun Lian
机构信息
Xinjiang Medical University, Urumqi 830054, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2007 Apr;32(8):729-31.
OBJECTIVE
To investigate the anti-aging effect of aqueous extract of Hedysarum austrosibiricum cultivated in Xin-jiang.
METHOD
Subacute aging model in mice was established by D-galactose (D-gal) and activities of SOD and GSH-PX, contents of MDA in brain and liver tissues, activities of MAO in brain tissue and immune indexes were determined.
RESULT
Aqueous extract of H. austrosibiricum Xinjiang markedly increased the activities of SOD and GSH-PX, significantly decreased contents of MDA in brain and liver tissues. MAO activities in brain tissue were also decreased. It also elevated the spleen and thymus indexes.
CONCLUSION
Aqueous extract of H. austrosibiricum might have anti-aging effect, which is implemented by eliminating oxyen free radicals, rising activities
目的
研究新疆栽培的准噶尔岩黄芪水提取物的抗衰老作用。
方法
用D-半乳糖建立小鼠亚急性衰老模型，测定脑和肝组织中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-PX）活性、丙二醛（MDA）含量、脑组织中单胺氧化酶（MAO）活性及免疫指标。
结果
新疆准噶尔岩黄芪水提取物显著提高SOD和GSH-PX活性，明显降低脑和肝组织中MDA含量，脑组织中MAO活性也降低，还提高了脾脏和胸腺指数。
结论
准噶尔岩黄芪水提取物可能具有抗衰老作用，其作用机制可能是通过清除氧自由基、提高抗氧化酶活性来实现的。
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