Centre for Biotechnology, Anna University, Chennai, Tamil Nadu, India.
Department of Periodontology and Oral Implantology, Sree Balaji Dental College and Hospital, Chennai, India.
Inflamm Res. 2019 May;68(5):347-349. doi: 10.1007/s00011-019-01230-2. Epub 2019 Mar 22.
CRP gene polymorphism is common in inflammatory diseases, but such association has not been reported in periodontitis. Our objective was to interrogate SNPs of crp in chronic periodontitis in a case-control manner.
DNAs were extracted from mouthwash samples of 116 volunteers using salting-out method. Selected 12 5'UTR SNPs of crp were genotyped using ARMS-PCR.
TC genotype of - 757T > C polymorphism (rs3093059) showed protective association (OR- 0.29, 95%CI-0.12-0.68, and p-0.004), and wild type - 757TT showed susceptible association with a p value of 0.008 (OR-3.09, 95%CI-1.33-7.15).
The observation of protective and susceptible association of crp - 757T > C polymorphism may be useful for better management and prophylaxis of periodontitis.
CRP 基因多态性在炎症性疾病中很常见，但在牙周炎中尚未有相关报道。本研究旨在采用病例对照的方法，探讨 CRP 基因多态性与慢性牙周炎的相关性。
采用盐析法从 116 名志愿者的漱口液样本中提取 DNA。采用 ARMS-PCR 方法对 CRP 的 12 个 5'UTR 单核苷酸多态性进行基因分型。
-757T>C 多态性（rs3093059）的 TC 基因型表现出保护作用（OR-0.29，95%CI-0.12-0.68，p=0.004），而野生型-757TT 则与牙周炎易感相关，p 值为 0.008（OR-3.09，95%CI-1.33-7.15）。
CRP-757T>C 多态性的保护性和易感性关联的观察结果可能有助于更好地管理和预防牙周炎。
