Heijsman Sigrid M, Koers Nicoline F, Bocca Gianni, van der Veen Betty S, Appelhof Maaike, Kamps Arvid W A
Department of Paediatrics, Medical Centre Leeuwarden, The Netherlands.
J Pediatr Endocrinol Metab. 2012;25(5-6):471-8. doi: 10.1515/jpem-2012-0054.
To determine the feasibility of non-invasive evaluation of adrenal response in healthy prepubertal children by standardized exercise tests.
On separate occasions, healthy prepubertal children performed a submaximal cycling test, a maximal cycling test, and a 20-m shuttle-run test. Salivary cortisol levels were determined before exercise, and 1 and 15 min after exercise.
Immediately after cessation of the cycling and shuttle-run tests, salivary cortisol levels remained unchanged or decreased. Fifteen minutes after the shuttle-run test, salivary cortisol levels increased significantly. This increase in salivary cortisol levels was not observed 15 min after the cessation of the cycling tests.
The results of this study demonstrate a different response in salivary cortisol levels after standardized cycling and running tests in prepubertal children. The increase in salivary cortisol levels found after a short standardized running test suggests that this may be a practical non-invasive method for evaluating adrenal response in healthy prepubertal children.
通过标准化运动测试确定对健康青春期前儿童肾上腺反应进行无创评估的可行性。
在不同时间，健康青春期前儿童分别进行次极量骑行测试、极量骑行测试和20米穿梭跑测试。在运动前、运动后1分钟和15分钟测定唾液皮质醇水平。
骑行和穿梭跑测试停止后即刻，唾液皮质醇水平保持不变或下降。穿梭跑测试后15分钟，唾液皮质醇水平显著升高。骑行测试停止15分钟后未观察到唾液皮质醇水平的这种升高。
本研究结果表明，青春期前儿童在标准化骑行和跑步测试后唾液皮质醇水平有不同反应。短时间标准化跑步测试后发现的唾液皮质醇水平升高表明，这可能是评估健康青春期前儿童肾上腺反应的一种实用无创方法。
