中国糖耐量正常人群血脂谱与胰岛β细胞功能的关系：一项横断面研究。
Relationship between blood lipid profiles and pancreatic islet β cell function in Chinese men and women with normal glucose tolerance: a cross-sectional study.
机构信息
Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, 610041, People's Republic of China.
出版信息
BMC Public Health. 2012 Aug 10;12:634. doi: 10.1186/1471-2458-12-634.
BACKGROUND
Dyslipidemia is present in people with diabetes as well as subjects with normal glucose tolerance (NGT). The purpose of this study was to investigate the relationship between lipid profiles and β cell function in Chinese individuals with NGT but without history of diabetes or prediabetes.
METHODS
A total of 893 men and 1454 women aged 18-76 years living in Sichuan, China, who were not being treated with lipid-lowering drugs were enrolled in this study. Insulin sensitivity (IR) was evaluated using the homeostasis model assessment -IR (HOMA-IR), β-cell function was calculated by the following equation: ΔI30/ΔG30/ HOMA-IR (ΔI30/ΔG30: the ratio of incremental glucose and insulin 30 min after glucose intake). Multivariate linear regression analyses were performed to estimate the relationship between blood lipid and β cell function as standardized coefficients (β).
RESULTS
β cell function decreased in men and women with increasing age. We found inverse relationships between β cell function and total cholesterol (TC) in men and women (β = -0.157 and -0.113, respectively, both p < 0.001), low-density lipoprotein-cholesterol (LDL-C; β = -0.130 and -0.068, respectively, both p < 0.001), TC/high-density lipoprotein-cholesterol (HDL-C) ratio (β = -0.084, p < 0.01 and -0.096, p < 0.001), and triglycerides (TG) (women only; β = -0.053, p < 0.05). However, β cell function was not associated with HDL-C in men or women (β = -0.034 and 0.000, respectively, both p > 0.05) or the TG/HDL-C ratio (β = -0.035 and -0.013, respectively, both p > 0.05). β cell function was significantly worse in males than in females in all age groups, except in subjects aged > 70 years.
CONCLUSIONS
Dyslipidemia is associated with dysfunction of pancreatic β cells in subjects with NGT and this is particularly evident in people with elevated TC and LDL-C levels, especially males.
TRIAL REGISTRATION NUMBER
#TR-CCH-Chi CTR-CCH-00000361.
背景
血脂异常存在于糖尿病患者以及糖耐量正常（NGT）的人群中。本研究的目的是探讨中国 NGT 人群中血脂谱与β细胞功能之间的关系，这些人群无糖尿病或糖尿病前期病史。
方法
共纳入 893 名男性和 1454 名年龄在 18-76 岁之间、未服用降脂药物的四川居民。使用稳态模型评估胰岛素抵抗（HOMA-IR）评估胰岛素敏感性（IR），通过以下公式计算β细胞功能：ΔI30/ΔG30/HOMA-IR（ΔI30/ΔG30：葡萄糖摄入后 30 分钟时葡萄糖和胰岛素的增量比）。使用标准化系数（β）进行多元线性回归分析，以评估血脂与β细胞功能之间的关系。
结果
β细胞功能随年龄增长在男性和女性中均呈下降趋势。我们发现男性和女性β细胞功能与总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）呈负相关（β分别为-0.157 和-0.113，均 p<0.001），与 TC/高密度脂蛋白胆固醇（HDL-C）比值（β分别为-0.084，p<0.01 和-0.096，p<0.001）和甘油三酯（TG）（仅女性；β=-0.053，p<0.05）呈负相关。然而，男性或女性的β细胞功能与 HDL-C 均无相关性（β分别为-0.034 和 0.000，均 p>0.05）或 TG/HDL-C 比值（β分别为-0.035 和-0.013，均 p>0.05）。除 70 岁以上的人群外，β细胞功能在所有年龄组中男性均显著差于女性。
结论
在 NGT 人群中，血脂异常与胰岛β细胞功能障碍有关，在 TC 和 LDL-C 水平升高的人群中更为明显，尤其是男性。
临床试验注册号
#TR-CCH-Chi CTR-CCH-00000361。
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