Department of Respiratory Medicine , The 452 Military Hospital of China, Chengdu, Sichuan 610041, China.
COPD. 2012 Aug;9(5):485-91. doi: 10.3109/15412555.2012.694921. Epub 2012 Aug 9.
The deletion/insertion (D/I) polymorphism in the angiotensin-converting enzyme (ACE) gene has been implicated in susceptibility of chronic obstruction pulmonary disease (COPD), but a number of studies have reported inconclusive results. The aim of this study is to investigate the relationship between the D/I polymorphism in the ACE gene and COPD risk by meta-analysis.
We searched Pubmed database, Embase database, CNKI database and Wanfang database, covering all studies until October 10, 2011. Statistical analysis was performed by using the software Revman4.2 and STATA 10.0.
A total of 710 COPD cases and 862 controls in 10 case-control studies were included in this study. The results suggested that the DD homozygote carriers did not have an increased or decreased risk of COPD when compared with the heterozygote DI and II homozygote carriers. However, in the subgroup analysis by race, significant increased risks were found in Asian DD homozygote carriers (OR = 2.6 and 95% CI = 1.47-4.57 for DD vs. DI+II) but not in Caucasian DD homozygote carriers (OR = 0.91, 95%CI = 0.69-1.22, P = 0.54 for DD vs. DI+II).
This meta-analysis suggested that the ACE gene is a COPD susceptible gene in Asian populations. Future studies are needed to validate our conclusions..
血管紧张素转换酶（ACE）基因的缺失/插入（D/I）多态性与慢性阻塞性肺疾病（COPD）的易感性有关，但许多研究的结果并不一致。本研究旨在通过荟萃分析来探讨 ACE 基因 D/I 多态性与 COPD 风险之间的关系。
我们检索了 Pubmed 数据库、Embase 数据库、中国知网（CNKI）数据库和万方数据库，检索时间截至 2011 年 10 月 10 日。采用 Revman4.2 和 STATA 10.0 软件进行统计学分析。
共有 10 项病例对照研究纳入了 710 例 COPD 患者和 862 例对照，结果表明 DD 纯合子携带者与 DI 和 II 杂合子携带者相比，患 COPD 的风险没有增加或降低。然而，在按种族亚组分析中，亚洲 DD 纯合子携带者患 COPD 的风险显著增加（OR=2.6，95%CI=1.47-4.57，DD 与 DI+II 相比），而高加索 DD 纯合子携带者则无此关联（OR=0.91，95%CI=0.69-1.22，P=0.54，DD 与 DI+II 相比）。
本荟萃分析表明 ACE 基因是亚洲人群 COPD 的易感基因。需要进一步的研究来验证我们的结论。
