Ma Yao, Tong Xiang, Liu Ying, Liu Sitong, Xiong Hai, Fan Hong
The Center of Gerontology and Geriatrics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China.
Department of Respiratory and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China,
Int J Chron Obstruct Pulmon Dis. 2018 Aug 13;13:2435-2446. doi: 10.2147/COPD.S168772. eCollection 2018.
Angiotensin-converting enzyme () gene I/D polymorphism has been studied in relation to the susceptibility to COPD and COPD with pulmonary hypertension (PH) with inconclusive results. We performed the first comprehensive meta-analysis to evaluate accurately the association between the gene polymorphism and the risk of COPD.
Data were analyzed using odds ratios (ORs) and the corresponding 95% CIs to measure the strength of the models. Subgroup analyses were conducted by ethnicity and complication which referred to PH.
In total, 15 studies (2,635 participants) were included in our study, of which four studies (288 participants) were for PH subgroup. The overall analysis results indicated that the gene polymorphism was not associated with COPD susceptibility in all gene models. However, the ethnic subgroup analysis results indicated that gene polymorphism was associated with Asians' susceptibility to COPD (DD+DI vs II, OR=1.47, =0.019, 95% CI: 1.07-2.02). Further, the overall results of the present study detected no statistical significance between gene polymorphism and the risk of COPD with PH, but the homozygote variant (DD) increased the risk of PH in Asian COPD patients (DD vs ID+II, OR=2.05, =0.05, 95% CI: 1.00-4.19).
The current study suggests that polymorphism, particularly the homozygote variant (DD), might contribute to the risk of COPD and COPD with PH among Asians. Further studies with larger sample size and more ethnicities are expected to be conducted in the future to validate the results.
血管紧张素转换酶（）基因I/D多态性与慢性阻塞性肺疾病（COPD）及合并肺动脉高压（PH）的COPD易感性的相关性研究结果尚无定论。我们进行了首次全面的荟萃分析，以准确评估该基因多态性与COPD风险之间的关联。
使用比值比（OR）和相应的95%置信区间（CI）分析数据，以衡量模型的强度。按种族和并发症（指PH）进行亚组分析。
我们的研究共纳入15项研究（2635名参与者），其中4项研究（288名参与者）用于PH亚组。总体分析结果表明，在所有基因模型中，该基因多态性与COPD易感性无关。然而，种族亚组分析结果表明，该基因多态性与亚洲人患COPD的易感性相关（DD + DI vs II，OR = 1.47，= 0.019，95% CI：1.07 - 2.02）。此外，本研究的总体结果未发现该基因多态性与合并PH的COPD风险之间存在统计学意义，但纯合子变体（DD）增加了亚洲COPD患者发生PH的风险（DD vs ID + II，OR = 2.05，= 0.05，95% CI：1.00 - 4.19）。
当前研究表明，该多态性，尤其是纯合子变体（DD），可能是亚洲人患COPD及合并PH的COPD的风险因素。未来有望进行更大样本量和更多种族的进一步研究以验证结果。
