Kang Sang Wook, Kim Su Kang, Chung Joo-Ho, Jung Hee-Jae, Kim Kwan-Il, Kim Jinju, Ban Ju Yeon
Department of Dental Pharmacology, School of Dentistry, Dankook University, Cheonan 31116, Republic of Korea.
Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Biomed Res Int. 2016;2016:7636123. doi: 10.1155/2016/7636123. Epub 2016 Oct 18.
The relationship between polymorphism of the angiotensin I converting enzyme () gene and chronic obstructive pulmonary disease (COPD) has been examined in many previous studies. However, their results were controversial. Therefore, we performed a meta-analysis to evaluate the relationship between the gene and the risk of COPD. Fourteen case-control studies were included in this meta-analysis. The pooled value, odds ratio (OR), and 95% confidence interval (95% CI) were used to investigate the strength of the association. The meta-analysis was performed using comprehensive meta-analysis software. Our meta-analysis results revealed that ACE polymorphisms were not related to the risk of COPD ( > 0.05 in each model). In further analyses based on ethnicity, we observed an association between insertion/deletion polymorphism of the gene and risk of COPD in the Asian population (codominant 2, OR = 3.126, 95% CI = 1.919-5.093, < 0.001; recessive, OR = 3.326, 95% CI = 2.190-5.050, < 0.001) but not in the Caucasian population ( > 0.05 in each model). In conclusion, the present meta-analysis indicated that the insertion/deletion polymorphism of the gene may be associated with susceptibility to COPD in the Asian population but not in the Caucasian population. However, the results of the present meta-analysis need to be confirmed in a larger sample.
此前已有许多研究探讨血管紧张素I转换酶（）基因多态性与慢性阻塞性肺疾病（COPD）之间的关系。然而，它们的结果存在争议。因此，我们进行了一项荟萃分析，以评估该基因与COPD风险之间的关系。这项荟萃分析纳入了14项病例对照研究。合并的 值、比值比（OR）和95%置信区间（95%CI）用于研究关联强度。使用综合荟萃分析软件进行荟萃分析。我们的荟萃分析结果显示，ACE基因多态性与COPD风险无关（各模型中>0.05）。在基于种族的进一步分析中，我们观察到该基因的插入/缺失多态性与亚洲人群的COPD风险之间存在关联（共显性模型2，OR = 3.126，95%CI = 1.919 - 5.093，<0.001；隐性模型，OR = 3.326，95%CI = 2.190 - 5.050，<0.001），但在白种人群中无关联（各模型中>0.05）。总之，本荟萃分析表明，该基因的插入/缺失多态性可能与亚洲人群而非白种人群的COPD易感性有关。然而，本荟萃分析的结果需要在更大样本中得到证实。
