Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Curr Med Chem. 2012;19(32):5459-66. doi: 10.2174/092986712803833164.
This review focuses on the recent findings that adiponectin plays a significant role of in cardiovascular diseases. Adipose tissue functions as an endocrine organ by secreting adipocytokines that can directly affect nearby or remote organs. Adiponectin is an adipocytokine whose concentration is down-regulated in subjects with obesity-related disorders. Low levels of circulating adiponectin appear to associate with the increased prevalence of obesity-linked diseases including atherosclerosis and ischemic heart disease. A number of experimental studies have shown that adiponectin exerts beneficial effects on the cardiovascular system by directly acting on the component cells in the heart and blood vessels. The cardiovascular protection by adiponectin is mediated through its ability to attenuate inflammatory responses and apoptotic activities in the target organs. Thus, adiponectin could represent a therapeutic target molecule for prevention or treatment of cardiovascular diseases.
这篇综述主要关注脂联素在心血管疾病中的重要作用。脂肪组织作为内分泌器官，通过分泌脂联素来直接影响附近或远处的器官。脂联素是一种脂肪细胞因子，在肥胖相关疾病患者中其浓度下调。循环脂联素水平低似乎与肥胖相关疾病的患病率增加有关，包括动脉粥样硬化和缺血性心脏病。许多实验研究表明，脂联素通过直接作用于心脏和血管中的靶细胞，对心血管系统发挥有益作用。脂联素的心血管保护作用是通过其减弱靶器官炎症反应和凋亡活性的能力来介导的。因此，脂联素可能是预防或治疗心血管疾病的治疗靶点分子。
