Giusti M, Cavagnaro P, Traverso L, Torre R
Cattedra di Endocrinologia, Università, Genova.
Recenti Prog Med. 1990 Nov;81(11):724-32.
The importance of gonadotropin pulsatility for normal hypothalamic-pituitary-gonadal axis function is well known. The most important aim of exogenous LHRH administration, given in females with delayed puberty or hypothalamic amenorrhea is to physiologically restore LH pulsatility to a more physiologic way as possible. In fact, a variable degree of LHRH endogenous defect is present in these conditions. Moreover, exogenous LHRH pulsatile administration is able to restore normal pubertal development until menarche appears and normal ovulatory cycles occur and pregnancy is induced. We reported our experience and review the literature regarding the importance and use of LHRH pulsatile therapy in delayed puberty and hypothalamic amenorrhea. We have also evaluated the data for various administration routes, the choice of patients, response to therapy and the possible diagnostic use of pulsatile LHRH with regard to the differential diagnosis of delayed puberty.
促性腺激素脉冲分泌对正常下丘脑-垂体-性腺轴功能的重要性已广为人知。对于青春期延迟或下丘脑性闭经的女性，给予外源性促黄体生成素释放激素（LHRH）的最重要目的是尽可能以更生理的方式在生理上恢复促黄体生成素（LH）的脉冲分泌。事实上，在这些情况下存在不同程度的内源性LHRH缺陷。此外，外源性LHRH脉冲给药能够恢复正常的青春期发育，直至月经初潮出现、正常排卵周期发生并诱导妊娠。我们报告了我们的经验，并回顾了关于LHRH脉冲疗法在青春期延迟和下丘脑性闭经中的重要性及应用的文献。我们还评估了各种给药途径的数据、患者的选择、对治疗的反应以及脉冲式LHRH在青春期延迟鉴别诊断方面可能的诊断用途。
