Department of General Surgery, Yixing People's Hospital, No. 75, Tongzhen Guan Rd., Yixing 214200, China.
Surgeon. 2013 Apr;11(2):67-71. doi: 10.1016/j.surge.2012.07.002. Epub 2012 Aug 9.
To evaluate the association between ADAM8 tissue expression and patient prognosis in hepatocellular carcinoma (HCC).
ADAM8 expression was analyzed using immunohistochemical staining methods on tissue samples from a consecutive series of 105 HCC patients who underwent resections between 2000 and 2006. The correlation of ADAM8 expression and patients' clinicopathological parameters was evaluated. Survival analysis was performed using the Kaplan-Meier method and Cox's proportional hazards model.
ADAM8 was highly expressed in 54.3% of the HCC patients. The ADAM8 expression level was closely associated with serum AFP elevation, tumor size, histological differentiation, tumor recurrence, tumor metastasis, and tumor stage. Kaplan-Meier survival analysis showed that a high expression level of ADAM8 resulted in a significantly poor prognosis of HCC patients. Multivariate analysis revealed that ADAM8 expression level was an independent prognostic parameter for the overall survival rate of HCC patients.
These findings provide evidence that a high expression level of ADAM8 serves as a biomarker for poor prognosis for HCC. Thus, we speculate that ADAM8 may be a potential target of antiangiogenic therapy for HCC.
评估 ADAM8 组织表达与肝细胞癌（HCC）患者预后之间的关系。
采用免疫组织化学染色方法，对 2000 年至 2006 年间连续接受手术切除的 105 例 HCC 患者的组织样本进行 ADAM8 表达分析。评估 ADAM8 表达与患者临床病理参数的相关性。采用 Kaplan-Meier 法和 Cox 比例风险模型进行生存分析。
ADAM8 在 54.3%的 HCC 患者中呈高表达。ADAM8 表达水平与血清 AFP 升高、肿瘤大小、组织学分化、肿瘤复发、肿瘤转移和肿瘤分期密切相关。Kaplan-Meier 生存分析显示，ADAM8 高表达导致 HCC 患者预后显著不良。多因素分析显示，ADAM8 表达水平是 HCC 患者总生存率的独立预后参数。
这些发现提供了证据表明，ADAM8 的高表达水平可作为 HCC 预后不良的生物标志物。因此，我们推测 ADAM8 可能是 HCC 抗血管生成治疗的潜在靶点。
