Brismar B, Edlund C, Malmborg A S, Nord C E
Department of Surgery, Huddinge University Hospital, Sweden.
Scand J Infect Dis Suppl. 1990;70:25-30.
During recent years the impact of different antimicrobial agents on the intestinal microflora in patients undergoing colorectal surgery has been investigated by our research group. Thus the effects on the microflora by parenteral administration of piperacillin, cefoxitin, cefbuperazone, moxalactam, aztreonam, imipenem, ampicillin + sulbactam, clindamycin, tinidazole, ciprofloxacin and ofloxacin have been studied. Pronounced changes were observed in the aerobic microflora in patients receiving ciprofloxacin and ofloxacin, in the anaerobic microflora in patients receiving clindamycin and tinidazole and in both the aerobic and anaerobic microflora in those patients receiving piperacillin, cefoxitin, cefbuperazone, moxalactam, aztreonam, imipenem and ampicillin + sulbactam. Postoperative infections were observed in patients receiving piperacillin (2), ampicillin + sulbactam (1), cefoxitin (1), aztreonam (3), tinidazole (6), clindamycin (5) and ofloxacin (5). In the patient groups receiving cefbuperazone, moxalactam, imipenem and ciprofloxacin, no postoperative infections occurred.
近年来，我们的研究小组对不同抗菌药物对接受结直肠手术患者肠道微生物群的影响进行了调查。因此，研究了静脉注射哌拉西林、头孢西丁、头孢哌酮、拉氧头孢、氨曲南、亚胺培南、氨苄西林+舒巴坦、克林霉素、替硝唑、环丙沙星和氧氟沙星对微生物群的影响。在接受环丙沙星和氧氟沙星的患者中，需氧微生物群出现明显变化；在接受克林霉素和替硝唑的患者中，厌氧微生物群出现明显变化；在接受哌拉西林、头孢西丁、头孢哌酮、拉氧头孢、氨曲南、亚胺培南和氨苄西林+舒巴坦的患者中，需氧和厌氧微生物群均出现明显变化。接受哌拉西林（2例）、氨苄西林+舒巴坦（1例）、头孢西丁（1例）、氨曲南（3例）、替硝唑（6例）、克林霉素（5例）和氧氟沙星（5例）的患者发生了术后感染。在接受头孢哌酮、拉氧头孢、亚胺培南和环丙沙星的患者组中，未发生术后感染。
