Departments of Biostatistics and Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109-5429, USA.
J Clin Endocrinol Metab. 2012 Nov;97(11):4051-60. doi: 10.1210/jc.2012-2117. Epub 2012 Aug 9.
Sex hormones may differ by race/ethnicity in postmenopausal women. Whether racial/ethnic differences also exist among those who are overweight and glucose intolerant is not clear.
The objective of the study was to compare sex hormones by race/ethnicity [non-Hispanic white (NHW), Hispanic, African-American (AA)] in overweight, glucose-intolerant, postmenopausal women.
This was a secondary analysis of a randomized controlled trial.
Participants included postmenopausal glucose-intolerant women participating in the Diabetes Prevention Program.
Interventions included intensive lifestyle modification (consisting of diet and physical activity) or metformin 850 mg twice a day vs. placebo.
Baseline levels and 1-yr intervention-related changes in SHBG, total and bioavailable estradiol (E2), total and bioavailable testosterone, and dehydroepiandrosterone were measured.
At baseline, among women not using estrogen (n = 370), NHW had higher total and bioavailable E2 and testosterone levels than Hispanics independent of age, type of menopause, waist circumference, alcohol intake, and current smoking. NHW also had higher levels of bioavailable E2 and lower levels of SHBG than AA. At baseline, among estrogen users (n = 310), NHW had higher total and bioavailable E2 than Hispanics and higher levels of SHBG than AA after adjustment. At 1 yr, among women not using estrogen, NHW had larger declines in total E2 and bioavailable E2 levels than AA after adjustment for the above covariates, changes in waist circumference, and randomization arm. At 1 yr, among estrogen users, sex hormone changes did not differ by race/ethnicity.
Among postmenopausal women, there were significant race/ethnicity differences in baseline sex hormones and changes in sex hormones.
绝经后女性的性激素可能因种族/民族而异。在超重和葡萄糖耐量受损的人群中，是否存在种族/民族差异尚不清楚。
本研究旨在比较超重、葡萄糖耐量受损、绝经后女性的种族/民族（非西班牙裔白人[NHW]、西班牙裔、非裔美国人[AA]）之间的性激素。
这是一项随机对照试验的二次分析。
参与者包括参加糖尿病预防计划的葡萄糖耐量受损的绝经后妇女。
干预措施包括强化生活方式改变（包括饮食和体育活动）或二甲双胍 850mg，每日两次，或安慰剂。
基线水平和 1 年干预相关的 SHBG、总和生物可利用雌二醇（E2）、总和生物可利用睾酮以及脱氢表雄酮的变化。
在未使用雌激素的女性（n=370）中，NHW 的总 E2 和生物可利用 E2 以及睾酮水平均高于西班牙裔，与年龄、绝经类型、腰围、酒精摄入量和当前吸烟状况无关。NHW 的生物可利用 E2 水平也高于 AA，SHBG 水平低于 AA。在使用雌激素的女性（n=310）中，调整上述协变量、腰围变化和随机分组后，NHW 的总 E2 和生物可利用 E2 水平均高于西班牙裔。1 年后，在未使用雌激素的女性中，调整上述协变量、腰围变化和随机分组后，NHW 的总 E2 和生物可利用 E2 水平下降幅度大于 AA。在使用雌激素的女性中，1 年后的性激素变化与种族/民族无关。
在绝经后女性中，基线性激素和性激素变化存在显著的种族/民族差异。
