荷兰与北莱茵-威斯特法伦（德国）耐甲氧西林金黄色葡萄球菌菌血症的跨境比较：一项横断面研究。
Cross border comparison of MRSA bacteraemia between The Netherlands and North Rhine-Westphalia (Germany): a cross-sectional study.
机构信息
Centre for Infectious Disease Control Netherlands, RIVM National Institute for Public Health and The Environment, Bilthoven, The Netherlands.
出版信息
PLoS One. 2012;7(8):e42787. doi: 10.1371/journal.pone.0042787. Epub 2012 Aug 3.
BACKGROUND
We describe the impact of methicillin-resistant Staphylococcus aureus (MRSA) in two neighbouring regions in Europe with a comparable population size, North Rhine-Westphalia (NRW) in Germany and the Netherlands.
METHODOLOGY/PRINCIPAL FINDINGS: We compared the occurrence of MRSA in blood cultures from surveillance systems. In the Netherlands in 2009, 14 of 1,510 (0.9%) Staphylococcus aureus bacteraemia episodes under surveillance were MRSA. Extrapolation using the number of clinical admissions results in a total of 29 MRSA bacteraemia episodes in the Netherlands or 1.8 episodes per 1,000,000 inhabitants. In 2010 in NRW, 1,029 MRSA bacteraemias were reported, resulting in 57.6 episodes of MRSA bacteraemia per 1,000,000 inhabitants: a 32-fold higher incidence than in the Netherlands.
CONCLUSION/SIGNIFICANCE: Based on an estimated attributable mortality of 15%, the Dutch approach would save approximately 150 lives per year by the prevention of bacteraemia only.
背景
我们描述了在人口规模相当的两个欧洲毗邻地区——德国北莱茵-威斯特法伦州（NRW）和荷兰——耐甲氧西林金黄色葡萄球菌（MRSA）的影响。
方法/主要发现：我们比较了监测系统中血培养中 MRSA 的发生情况。2009 年，荷兰在监测的 1510 例金黄色葡萄球菌菌血症中，有 14 例（0.9%）为耐甲氧西林金黄色葡萄球菌。根据住院人数进行推断，荷兰共有 29 例耐甲氧西林金黄色葡萄球菌菌血症，每 100 万人中有 1.8 例。2010 年，NRW 报告了 1029 例耐甲氧西林金黄色葡萄球菌菌血症，每 100 万人中有 57.6 例耐甲氧西林金黄色葡萄球菌菌血症：发病率是荷兰的 32 倍。
结论/意义：仅通过预防菌血症，荷兰方法每年可通过预防菌血症挽救约 150 条生命，基于估计的 15%的归因死亡率。
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