Desouza Melissa, Gunning Peter W, Stehn Justine R
Oncology Research Unit; School of Medical Sciences; The University of New South Wales; Sydney, Australia.
Bioarchitecture. 2012 May 1;2(3):75-87. doi: 10.4161/bioa.20975.
Apoptosis is an important biological process required for the removal of unwanted or damaged cells. Mounting evidence implicates the actin cytoskeleton as both a sensor and mediator of apoptosis. Studies also suggest that actin binding proteins (ABPs) significantly contribute to apoptosis and that actin dynamics play a key role in regulating apoptosis signaling. Changes in the organization of the actin cytoskeleton has been attributed to the process of malignant transformation and it is hypothesized that remodeling of the actin cytoskeleton may enable tumor cells to evade normal apoptotic signaling. This review aims to illuminate the role of the actin cytoskeleton in apoptosis by systematically analyzing how actin and ABPs regulate different apoptosis pathways and to also highlight the potential for developing novel compounds that target tumor-specific actin filaments.
细胞凋亡是清除不需要的或受损细胞所必需的重要生物学过程。越来越多的证据表明，肌动蛋白细胞骨架既是细胞凋亡的传感器，也是其介导者。研究还表明，肌动蛋白结合蛋白（ABP）对细胞凋亡有显著贡献，并且肌动蛋白动力学在调节细胞凋亡信号传导中起关键作用。肌动蛋白细胞骨架组织的变化被认为与恶性转化过程有关，据推测，肌动蛋白细胞骨架的重塑可能使肿瘤细胞逃避正常的细胞凋亡信号。本综述旨在通过系统分析肌动蛋白和ABP如何调节不同的细胞凋亡途径，阐明肌动蛋白细胞骨架在细胞凋亡中的作用，并强调开发靶向肿瘤特异性肌动蛋白丝的新型化合物的潜力。
