重组人亲环素 A 在体外抑制纤维蛋白凝块的形成。
Recombinant Human Cyclophilin A in vitro Inhibits the Formation of Fibrin Clot.
机构信息
Petrovsky Russian Research Center of Surgery, Russian Academy of Medical Sciences.
出版信息
Acta Naturae. 2012 Apr;4(2):98-101.
Abstract
The chemotactic properties of cyclophilin A are well-known. There exists however a poor level of understanding regarding the hemostatic effects of this protein. Herein it is shown that recombinant human cyclophilin A (rhСyA), in contrast to the granulocyte colony-stimulating factor, is capable of inhibitingin vitrothe formation of a fibrin clot, thereby violating the spatial dynamics of clot growth; this effect is transient and dose-independent. Furthermore, the hypothesis that the conformational changes in the thrombin-rhCyA complex may mediate the anticoagulant effect of rhCyA on the autowave processes of blood clotting is postulated.
摘要
亲环素 A 的趋化特性是众所周知的。然而，人们对这种蛋白质的止血作用知之甚少。本文表明，与粒细胞集落刺激因子相反，重组人亲环素 A（rhCyA）能够抑制体外纤维蛋白凝块的形成，从而破坏凝块生长的空间动力学；这种效应是短暂的，与剂量无关。此外，还假设凝血酶-rhCyA 复合物的构象变化可能介导 rhCyA 对血液凝固自波过程的抗凝作用。
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本文引用的文献
1
Cyclophilin A produced by thymocytes regulates the migration of murine bone marrow cells.胸腺细胞产生的亲环素A调节小鼠骨髓细胞的迁移。
Cell Immunol. 2007 Sep;249(1):46-53. doi: 10.1016/j.cellimm.2007.11.002. Epub 2007 Dec 20.
2
Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.对活化血小板释放的蛋白质进行表征，可确定新型血小板蛋白在人类动脉粥样硬化病变中的定位。
Blood. 2004 Mar 15;103(6):2096-104. doi: 10.1182/blood-2003-08-2804. Epub 2003 Nov 20.
3
Spatiotemporal dynamics of contact activation factors of blood coagulation.
Biochim Biophys Acta. 2002 Jan 15;1569(1-3):86-104. doi: 10.1016/s0304-4165(01)00247-1.
4
Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide reductase.磷酸甘油酸激酶在肿瘤血管生成中作为二硫键还原酶发挥作用。
Nature. 2000 Dec 14;408(6814):869-73. doi: 10.1038/35048596.
5
[Spatial aspects of the dynamics of blood coagulation. II. Phenomenological model].
Biofizika. 1994 Jan-Feb;39(1):97-106.
6
[Spatial aspects of the dynamics of blood coagulation. I. Hypothesis].[血液凝固动力学的空间方面。I. 假说]
Biofizika. 1994 Jan-Feb;39(1):89-96.
7
[Threshold behavior of the blood coagulation system upon changes in calcium concentration].
Biofizika. 1994 Jul-Aug;39(4):713-20.
8
Blood coagulation. The thrombin paradox.血液凝固。凝血酶悖论。
Nature. 1995 Nov 23;378(6555):337-8. doi: 10.1038/378337a0.
9
10
Leukocyte chemotactic activity of cyclophilin.亲环蛋白的白细胞趋化活性。
J Biol Chem. 1992 Jun 15;267(17):11968-71.
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