Gürgey A, Ozsoylu S, Hiçsönmez G, Irken G, Altay C
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
Turk J Pediatr. 1990 Jan-Mar;32(1):39-41.
A 13-year-old girl with acute lymphoblastic leukemia is presented. The peripheral smear showed, in addition to lymphoblasts, marked anisocytosis, poikilocytosis, and polychromasia. In vitro sickling test was positive. Hemoglobin electrophoresis at pH 9.0 on starch gel revealed the presence of hemoglobin A, hemoglobin S, and a band with a mobility of hemoglobin A2. Structural analysis revealed the presence of hemoglobin S and an alpha-chain variant, hemoglobin Q-Iran. The patient attained remission with the initial therapy administered but a relapse occurred five months later. Our study indicates the need for detailed investigation of leukemia patients in which abnormal hemoglobins are prevalent.
报告一名患有急性淋巴细胞白血病的13岁女孩。外周血涂片显示，除了原始淋巴细胞外，还存在明显的红细胞大小不均、异形红细胞症和嗜多色性。体外镰状试验呈阳性。在pH 9.0的淀粉凝胶上进行血红蛋白电泳显示存在血红蛋白A、血红蛋白S以及一条迁移率与血红蛋白A2相同的条带。结构分析显示存在血红蛋白S和一种α链变体——血红蛋白Q-伊朗型。患者接受初始治疗后病情缓解，但五个月后复发。我们的研究表明，对于血红蛋白异常普遍存在的白血病患者，需要进行详细调查。
