Division of Nephrology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong (SAR), PR China.
Ren Fail. 2012;34(8):980-4. doi: 10.3109/0886022X.2012.706878.
Vitamin D deficiency is common globally. There is evidence that vitamin D status may be related to immune function and cardiovascular disease. The vitamin D status of Chinese kidney transplant recipients has never been investigated. We performed a cross-sectional study and measured the level of 25-hydroxyvitamin D [25(OH)D] in 94 Chinese renal transplant recipients with stable allograft function. Vitamin D deficiency and insufficiency were detected in 43.6% and 54.2% of patients, respectively. About 53.2% of the patients also had elevated parathyroid hormone (PTH) levels. The level of 25(OH)D was lower in kidney transplant recipients compared with healthy controls matched for age and sex (52.5 ± 15.6 nmol/L vs. 57.5 ± 19.0 nmol/L, p = 0.05), but the level of serum creatinine was higher in kidney transplant recipients (120.3 ± 48.5 μmol/L and 78.3 ± 15.3 μmol/L, p < 0.01). The level of 25(OH)D was negatively correlated with that of PTH (p = 0.001). The latter was associated with serum creatinine (p = 0.001) and duration of dialysis (p = 0.001). Patients with a history of acute rejection showed lower levels of 25(OH)D (45.3 ± 11.9 nmol/L vs. 54.2 ± 16.0 nmol/L, p = 0.003). We conclude that vitamin D deficiency is prevalent among Chinese renal transplant recipients. In view of the potential immunomodulatory effect of vitamin D, the relationship between vitamin D level and rejection and the effect of vitamin D supplementation in renal transplant recipients warrant further investigations.
维生素 D 缺乏症在全球范围内很常见。有证据表明，维生素 D 状况可能与免疫功能和心血管疾病有关。中国肾移植受者的维生素 D 状况从未被调查过。我们进行了一项横断面研究，测量了 94 例肾功能稳定的肾移植受者的 25-羟维生素 D [25(OH)D]水平。分别有 43.6%和 54.2%的患者存在维生素 D 缺乏和不足。约 53.2%的患者甲状旁腺激素（PTH）水平也升高。与年龄和性别相匹配的健康对照组相比，肾移植受者的 25(OH)D 水平较低（52.5±15.6 nmol/L 比 57.5±19.0 nmol/L，p=0.05），但肾移植受者的血清肌酐水平较高（120.3±48.5 μmol/L 比 78.3±15.3 μmol/L，p<0.01）。25(OH)D 水平与 PTH 呈负相关（p=0.001）。后者与血清肌酐（p=0.001）和透析时间（p=0.001）有关。有急性排斥反应史的患者 25(OH)D 水平较低（45.3±11.9 nmol/L 比 54.2±16.0 nmol/L，p=0.003）。我们的结论是，维生素 D 缺乏症在中国肾移植受者中很常见。鉴于维生素 D 具有潜在的免疫调节作用，维生素 D 水平与排斥反应之间的关系以及维生素 D 补充在肾移植受者中的作用值得进一步研究。
