通过简易常压超声喷雾电离质谱法（EASI-MS）对街头毒品吸墨纸样本中的麦角酸二乙酰胺（LSD）和9,10-二氢麦角酸二乙酰胺进行分析。

LSD and 9,10-dihydro-LSD analyses in street drug blotter samples via easy ambient sonic-spray ionization mass spectrometry (EASI-MS).

作者信息

Romão Wanderson, Sabino Bruno D, Bueno Maria Izabel M S, Vaz Boniek G, Júnior Amadeu C, Maldaner Adriano O, de Castro Eustáquio V R, Lordeiro Rogério A, Nascentes Clésia C, Eberlin Marcos N, Augusti Rodinei

机构信息

ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, State University of Campinas-UNICAMP, Campinas, SP, Brazil.

出版信息

J Forensic Sci. 2012 Sep;57(5):1307-12. doi: 10.1111/j.1556-4029.2012.02237.x. Epub 2012 Aug 6.

DOI:10.1111/j.1556-4029.2012.02237.x

PMID:22880936

Abstract

Normally, the identification of the LSD drug is performed by forensic laboratories, using the Ehrlich spot test. However, this is a nonspecific analysis. Additionally, the Brazilian Federal Police has identified the presence of a new compound in seized blotters: 9,10-dihydro-LSD, an uncontrolled substance. In this work, easy ambient sonic-spray ionization mass spectrometry in the positive ion mode, EASI(+)-MS, was used to characterize LSD and 9,10-dihydro-LSD compositions directly from the surface of blotters. The presence of LSD in the seized blotter samples were also confirmed via high-performance liquid chromatography with ultraviolet detector. In a set of 41 blotters analyzed by EASI(+)-MS, 28 showed positive results for LSD, seven for 9,10-dihydro-LSD, and another six samples showed negative results for both LSD and 9,10-dihydro-LSD. The combination of thin layer chromatography with EASI-MS also demonstrated to be a relatively simple and powerful screening tool for forensic analysis of street drugs.

摘要

通常，LSD药物的鉴定由法医实验室使用埃利希斑点试验进行。然而，这是一种非特异性分析。此外，巴西联邦警察在查获的吸墨纸上发现了一种新化合物：9,10-二氢-LSD，一种未受管制的物质。在这项工作中，采用正离子模式的简易常压声波喷雾电离质谱法（EASI(+)-MS）直接从吸墨纸表面对LSD和9,10-二氢-LSD成分进行表征。通过配备紫外检测器的高效液相色谱法也证实了查获的吸墨纸样品中存在LSD。在通过EASI(+)-MS分析的41份吸墨纸中，28份对LSD呈阳性结果，7份对9,10-二氢-LSD呈阳性结果，另外6份样品对LSD和9,10-二氢-LSD均呈阴性结果。薄层色谱法与EASI-MS的结合也被证明是一种相对简单且强大的街头毒品法医分析筛选工具。