School of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.
J Am Geriatr Soc. 2012 Aug;60(8):1571-5. doi: 10.1111/j.1532-5415.2012.04057.x. Epub 2012 Aug 6.
The deep-seated faith in tight glycemic control for patients with type 2 diabetes mellitus shows signs of moderating, especially for elderly adults, but faith in the importance of a glycosylated hemoglobin goal of 7% retains a strong influence over many clinicians. This faith persists despite weak evidence from randomized controlled trials of any meaningful benefit from "tight control" in any patient group, consistent evidence of lack of benefit for many outcomes, and an almost complete lack of evidence about elderly adults or those with extensive vascular disease. Clinicians who care for these vulnerable individuals face a strong public belief in "tight control" and an orchestrated campaign to increase medication use. Although no benefit has been shown in elderly adults, some harms are clear, and others are likely.
对于 2 型糖尿病患者进行严格血糖控制的根深蒂固的信念表现出缓和的迹象,特别是对于老年人,但对于糖化血红蛋白目标为 7%的重要性的信念仍然对许多临床医生有很大的影响。尽管随机对照试验的证据表明,在任何患者群体中,“严格控制”都没有任何有意义的益处,但这种信念仍然存在,而且缺乏对许多结果有益的一致证据,也几乎完全缺乏关于老年人或广泛血管疾病患者的证据。照顾这些脆弱人群的临床医生面临着公众对“严格控制”的强烈信念和增加药物使用的精心策划的运动。尽管在老年人中没有显示出益处,但一些危害是明确的,其他危害也可能存在。