Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA.
Endocrinol Metab Clin North Am. 2013 Jun;42(2):333-47. doi: 10.1016/j.ecl.2013.02.010. Epub 2013 Mar 22.
Diabetes and impaired glucose tolerance affect a substantial proportion of older adults. Abnormal glucose metabolism is not a necessary component of aging. Older adults with diabetes and altered glucose status likely represent a subset of the population at high risk for complications and adverse geriatric syndromes. Goals for treatment of diabetes in the elderly include control of hyperglycemia, prevention and treatment of diabetic complications, avoidance of hypoglycemia, and preservation of quality of life. Research exploring associations of dysglycemia and insulin resistance with the development of adverse outcomes in the elderly may ultimately inform use of future glucose-lowering therapies in this population.
糖尿病和葡萄糖耐量受损影响了相当一部分老年人。异常的葡萄糖代谢并不是衰老的必要组成部分。患有糖尿病和葡萄糖状态改变的老年人可能代表了一个高危人群,他们容易出现并发症和不良老年综合征。老年糖尿病治疗的目标包括控制高血糖、预防和治疗糖尿病并发症、避免低血糖以及保持生活质量。研究探索了血糖异常和胰岛素抵抗与老年人不良结局发展之间的关系,这可能最终为这一人群使用未来的降糖治疗提供依据。