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西班牙 65 岁以上 2 型糖尿病患者血糖控制不佳及治疗管理情况。

Inadequate Glycaemic Control and Therapeutic Management of Adults over 65 Years Old with Type 2 Diabetes Mellitus in Spain.

机构信息

Francesc Formiga, Geriatric Unit, Internal Medicine Department, Hospital Universitari de Bellvitge-IDIBELL, c/Feixa Llarga, s/n, 08907 L'Hospitalet de Llobregat, Barcelona (Spain), Tel.: + 34 932 607 699, Fax: +34 932 607 967, E-mail:

出版信息

J Nutr Health Aging. 2017;21(10):1365-1370. doi: 10.1007/s12603-017-0869-4.

Abstract

OBJECTIVES

The glycaemic goals for older patients with type 2 diabetes mellitus (DM) are recommended to avoid an HbA1c levels <7%. The purpose of this study was to analyse the glycaemic control and therapeutic management of older adults (≥65 years) with type 2 DM.

DESIGN

Pooled analysis of patients enrolled in three Spanish cross-sectional epidemiological studies.

SETTING

The study was conducted between 2009 and 2011 by primary care or specialist physicians.

PARTICIPANTS

A total of 7,269 patients aged ≥65 years with type 2 DM.

MEASUREMENTS

Sociodemographic, medical history, lifestyle habits, biochemical laboratory parameters, comorbidities, type 2 DM complications, and pharmacological treatment data collected from medical records.

RESULTS

In total, data from 7,269 patients were analysed (mean age 73.4 years old; 48.4% male). A total of 10.9% of patients had HbA1c levels ≥8.5% and 43.2% <7%. The most common comorbidities were hypertension (82.0%) and dyslipidaemia (76.6%). The microvascular complications were mainly diabetic nephropathy (23.6%) and retinopathy (19.3%). Oral antidiabetic drugs (OADs) were taken by 70.5% of patients (sulphonylureas 65.3%), 4.1% were taking insulin alone and 25.4% took both insulin and an OAD. Half of the patients (51.0%) were taking a combination of OADs.

CONCLUSION

In conclusion, more than half of older patients with type 2 DM had unsatisfactory management: approximately one in ten had inadequate glycaemic control (HbA1c ≥8.5%) despite hypoglycaemic drugs and four in ten were potentially overtreated (HbA1c <7%).

摘要

目的

对于 2 型糖尿病(DM)老年患者,建议避免 HbA1c 水平<7%。本研究旨在分析 2 型 DM 老年患者(≥65 岁)的血糖控制和治疗管理情况。

设计

对三项西班牙横断面流行病学研究中纳入的患者进行汇总分析。

地点

本研究由初级保健或专科医生于 2009 年至 2011 年开展。

参与者

共纳入 7269 例年龄≥65 岁的 2 型 DM 患者。

测量

从病历中收集患者的社会人口统计学、病史、生活方式习惯、生化实验室参数、合并症、2 型 DM 并发症和药物治疗数据。

结果

共分析了 7269 例患者的数据(平均年龄 73.4 岁;48.4%为男性)。有 10.9%的患者 HbA1c 水平≥8.5%,有 43.2%的患者 HbA1c<7%。最常见的合并症为高血压(82.0%)和血脂异常(76.6%)。微血管并发症主要为糖尿病肾病(23.6%)和视网膜病变(19.3%)。70.5%的患者服用口服降糖药(OADs)(磺脲类药物 65.3%),4.1%单独使用胰岛素,25.4%同时使用胰岛素和 OAD。有一半的患者(51.0%)服用 OAD 联合药物。

结论

总之,超过一半的 2 型 DM 老年患者的治疗管理不理想:尽管使用了降血糖药物,仍有约十分之一的患者血糖控制不达标(HbA1c≥8.5%),而四分之一的患者可能治疗过度(HbA1c<7%)。

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