GABRA2 基因型、冲动性与体重。
GABRA2 genotype, impulsivity, and body mass.
机构信息
Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030-2103, USA.
出版信息
Am J Addict. 2012 Sep-Oct;21(5):404-10. doi: 10.1111/j.1521-0391.2012.00252.x.
BACKGROUND
The goal of this study was to test a hypothesis associating impulsivity with an elevated body mass index (BMI).
METHODS
To this end, we examined associations of BMI with putative genetic, neurophysiological, psychiatric, and psychological indicators of impulsivity in 78 women and 74 men formerly dependent on alcohol or drugs. A second analysis was designed to test the replicability of the genetic findings in an independent sample of 109 women and 111 men with a similar history of substance dependence.
RESULTS
The results of the first analysis showed that BMI was positively correlated with Total and Nonplanning Scale Scores on the Barratt Impulsiveness Scale and the number of childhood symptoms of Attention-Deficit/Hyperactivity Disorder in women. It was also positively correlated, in women, with a GABRA2 variant previously implicated as a risk factor for substance dependence and an objective electroencephalographic feature previously associated with GABRA2 and relapse risk. The second analysis confirmed that the correlation between BMI and the substance-dependence-associated GABRA2 genotype was reliable and sex-specific.
CONCLUSIONS
We conclude that an elevated BMI is associated with genetic, neurophysiological, psychiatric, and psychological indicators of impulsivity. The sex difference may be explained by greater opportunities to eat and overeat, a preference for higher calorie foods, a longer duration of alcohol/drug abstinence, or previous pregnancies in women.
背景
本研究旨在验证一个假设，即冲动性与较高的体重指数（BMI）有关。
方法
为此，我们在 78 名女性和 74 名曾经依赖酒精或药物的男性中，检查了 BMI 与冲动性的潜在遗传、神经生理、精神和心理指标之间的关联。第二项分析旨在测试在具有类似物质依赖史的 109 名女性和 111 名男性的独立样本中，遗传发现的可重复性。
结果
第一项分析的结果表明，BMI 与女性巴雷特冲动量表的总评分和非计划评分以及儿童注意力缺陷/多动障碍症状的数量呈正相关。在女性中，它还与先前被认为是物质依赖风险因素的 GABRA2 变体以及先前与 GABRA2 和复发风险相关的客观脑电图特征呈正相关。第二项分析证实，BMI 与与物质依赖相关的 GABRA2 基因型之间的相关性是可靠的且具有性别特异性。
结论
我们得出结论，较高的 BMI 与冲动性的遗传、神经生理、精神和心理指标有关。性别差异可能是由于女性有更多的进食和暴饮暴食的机会、对高热量食物的偏好、更长时间的酒精/药物戒断或之前的怀孕。
Zotero 插件