Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
BJU Int. 2013 Mar;111(3 Pt B):E92-7. doi: 10.1111/j.1464-410X.2012.11422.x. Epub 2012 Aug 9.
Study Type - Prognosis (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Interstitial cystitis/painful bladder syndrome (IC/PBS) comprises pain perceived to be from the bladder, urinary urgency and frequency, and nocturia. As diagnosed at present, it is primarily identified in adult women. It is a chronic disease yet its natural history has not been well studied. In a prospective study of 304 incident female IC/PBS cases followed for a median of 33 months after onset, women with baseline chronic fatigue syndrome had a worse prognosis for IC/PBS. Mild IC/PBS at baseline was the only variable that was directly associated with a good prognosis.
To identify baseline variables that predict the prognosis of interstitial cystitis/painful bladder syndrome (IC/PBS) in women seeking medical care for recent onset of this syndrome.
In a prospective study of women with incident IC/PBS (≤12 months of symptoms), we contacted patients at intervals and asked standardized questions about IC/PBS symptoms in the previous week. Logistic regression analyses assessed baseline variables as predictors of mild vs more severe IC/PBS at the last follow-up.
Median length of follow-up was 33 months after onset of IC/PBS; 304 (97%) patients had at least one follow-up assessment. Mild IC/PBS at baseline was the only variable that was directly associated with a mild IC/PBS endpoint. Conversely, a history of chronic fatigue syndrome (CFS) was inversely associated with a mild endpoint of IC/PBS (i.e. individuals with CFS had a worse prognosis for their IC/PBS symptoms).
At a median of nearly 3 years after onset, baseline mild IC/PBS was directly associated with a milder disease severity. Baseline co-morbid CFS was associated with more severe disease. Whether CFS was uniquely associated or represented several co-morbid non-bladder syndromes (NBSs) could not be determined.
确定基线变量，以预测女性就医近期出现间质性膀胱炎/膀胱疼痛综合征（IC/PBS）的预后。
在一项对新发 IC/PBS（≤12 个月症状）的女性进行的前瞻性研究中，我们在间隔时间联系患者，并询问他们在过去一周内关于 IC/PBS 症状的标准化问题。逻辑回归分析评估了基线变量作为最后一次随访时轻度与更严重 IC/PBS 的预测因子。
IC/PBS 发病后中位随访时间为 33 个月；304 名（97%）患者至少有一次随访评估。基线轻度 IC/PBS 是唯一与轻度 IC/PBS 终点直接相关的变量。相反，慢性疲劳综合征（CFS）病史与 IC/PBS 的轻度终点呈负相关（即患有 CFS 的个体其 IC/PBS 症状预后更差）。
在发病后近 3 年的中位时间，基线轻度 IC/PBS 与更轻的疾病严重程度直接相关。基线共存 CFS 与更严重的疾病相关。CFS 是否是唯一相关的因素还是代表了几种共存的非膀胱综合征（NBS）尚无法确定。
