Zhang Xiao-ting, Zhao Dong, Liu Jing, Feng Li-qun, Sun Jia-yi, Wang Miao, Liu Jun, Wang Wei
Department of Epidemiology, Capital Medical University Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2012 May;33(5):455-9.
To evaluate the association between triglyceride (TG) level and newly identified 5-year carotid plaque and to explore the prediction value of TG level on the newly-identified carotid plaque with risk factors of traditional atherosclerosis.
A cohort study was adopted. The baseline survey including CVD risk factors and B-mode ultrasound of carotid artery was performed in 2002, and the second follow-up examination was performed in 2007. We evaluated 1949 participants with lipid measurements and B-mode ultrasound of carotid arteries in the two surveys (with mean age as 57.9±8.1 years and 39.2% were men). The baseline TG levels were divided into four groups: group 1 (TG<1.13 mmol/L), group 2 (TG=1.13-1.69 mmol/L), group 3 (TG=1.70-2.25 mmol/L) and group 4 (TG≥2.26 mmol/L). Newly identified carotid plaque was regarded as the indicator of progression of carotid atherosclerosis. New relationship between fasting TG levels and newly identified carotid plaque was analysed.
Compared to newly identified carotid plaque which including different TG level groups, the incidence of newly artery plaque had significantly increased along with the increase of baseline triglyceride level (30.8%, 38.8%, 41.9% and 44.2% respectively, with χ2=21.22, P<0.01). Compared to individuals (TG<1.13 mmol/L), TG seemed a risk factor of plaque progression (P<0.01). After adjusted for age, sex, dyslipidemia and other risk factors, high TG group (TG≥2.26 mmol/L) appeared a significant independent predictor of newly identified carotid plaque (OR=1.37, 95%CI: 1.00-1.86). When further stratifying the traditional atherosclerosis risk factors, we found that high TG group with smoking or hypertension was an independent factor of atherosclerosis progression.
With the increase of triglyceride levels, the rate of newly identified carotid plaque also increased. After adjusting age, sex, dyslipidemia and other risk factors, serum fasting TG≥2.26 mmol/L appeared to be an independent predictor of newly developed carotid plaque.
评估甘油三酯（TG）水平与新发现的5年颈动脉斑块之间的关联，并探讨TG水平对伴有传统动脉粥样硬化危险因素的新发现颈动脉斑块的预测价值。
采用队列研究。2002年进行了包括心血管疾病危险因素和颈动脉B超检查在内的基线调查，并于2007年进行了第二次随访检查。我们评估了两次调查中1949名进行血脂测量和颈动脉B超检查的参与者（平均年龄为57.9±8.1岁，男性占39.2%）。基线TG水平分为四组：第1组（TG<1.13 mmol/L）、第2组（TG=1.13 - 1.69 mmol/L）、第3组（TG=1.70 - 2.25 mmol/L）和第4组（TG≥2.26 mmol/L）。新发现的颈动脉斑块被视为颈动脉粥样硬化进展的指标。分析空腹TG水平与新发现颈动脉斑块之间的新关系。
与包括不同TG水平组的新发现颈动脉斑块相比，新动脉斑块的发生率随着基线甘油三酯水平的升高而显著增加（分别为30.8%、38.8%、41.9%和44.2%，χ2 = 21.22，P<0.01）。与TG<1.13 mmol/L的个体相比，TG似乎是斑块进展的危险因素（P<0.01）。在调整年龄、性别、血脂异常和其他危险因素后，高TG组（TG≥2.26 mmol/L）是新发现颈动脉斑块的显著独立预测因素（OR = 1.37，95%CI：1.00 - 1.86）。当进一步对传统动脉粥样硬化危险因素进行分层时，我们发现吸烟或患有高血压的高TG组是动脉粥样硬化进展的独立因素。
随着甘油三酯水平的升高，新发现颈动脉斑块的发生率也增加。在调整年龄、性别、血脂异常和其他危险因素后，空腹血清TG≥2.26 mmol/L似乎是新发生颈动脉斑块的独立预测因素。
