Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK.
Cell Metab. 2012 Aug 8;16(2):139-41. doi: 10.1016/j.cmet.2012.07.009.
Why upregulation of the transcription factor Nrf2 increases tumor cell proliferation is unclear. Mitsuishi et al. (2012) now provide evidence that Nrf2 augments purine nucleotide synthesis, thus supporting tissue hypertrophy. This change in cellular metabolism requires loss of Nrf2 repression by Keap1 as well as costimulation via the PI3K-Akt pathway.
转录因子 Nrf2 的上调为何会增加肿瘤细胞的增殖尚不清楚。Mitsuishi 等人（2012 年）现在提供了证据，表明 Nrf2 增强嘌呤核苷酸的合成，从而支持组织肥大。这种细胞代谢的变化需要 Keap1 对 Nrf2 的抑制作用丧失，以及通过 PI3K-Akt 途径的共刺激作用。
