Wei Sheng, Hou Jin-Liang, Chao Yu-Bin, Du Xi-Yang, Zong Shao-Bo
Key Laboratory of Classics Theory of Traditional Chinese Medicine of the Ministry of Education of China, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China.
Zhong Xi Yi Jie He Xue Bao. 2012 Aug;10(8):925-31. doi: 10.3736/jcim20120814.
To observe the changes in content of monoamine neurotransmitters in the serum of rhesus macaques, and explore the role of serum monoamine neurotransmitters in premenstrual syndrome (PMS) and liver-qi depression induced by anger-in emotion.
Social level pressure was applied on 24 female macaques to induce the angry emotional reaction, and then nine of the low-status macaques with anger-in emotional reaction were screened out and were divided into anger-in emotion group, PMS and liver-qi depression group (model group) and Jingqianshu Granule group. Macaques in the last two groups were suffered extruding in a pack cage for inducing PMS liver-qi depression. After 5 d of extruding, experimental animals were evaluated according to the emotional evaluation scale, meanwhile, macaque serum of follicular phase and middle-late luteal phase was collected to analyze the content of serum norepinephrine, dopamine, and 5-hydroxytryptamine.
Compared with the normal control group, the scores of depression of the model group and the anger-in emotion group evaluated with emotional evaluation scale were significantly increased (P<0.01, P<0.05); while the score of the model group was significantly higher than that of the anger-in emotion group (P<0.05), and it returned to normal after Jingqianshu Granule treatment. As compared to the normal control group, serum monoamine neurotransmitter levels of the model group and the anger-in emotion group were increased (P<0.05, P<0.01), and the serum monoamine neurotransmitter levels of the model group were significantly higher than those of the anger-in emotion group (P<0.05), while there was no significant difference when compared with the normal control group after the treatment.
Anger-in emotion can induce liver-qi depression syndrome which is related to the changes in monoamine neurotransmitters.
观察恒河猴血清中单胺类神经递质含量的变化，探讨血清单胺类神经递质在经前期综合征（PMS）及怒伤肝致肝气郁证中的作用。
对24只雌性恒河猴施加社会等级压力诱导愤怒情绪反应，筛选出9只出现怒伤肝情绪反应的低等级恒河猴，分为怒伤肝组、PMS肝气郁证组（模型组）和经前舒颗粒组。后两组恒河猴在拥挤笼中挤压以诱导PMS肝气郁证。挤压5 d后，根据情绪评价量表对实验动物进行评价，同时采集卵泡期及黄体中晚期恒河猴血清，分析血清去甲肾上腺素、多巴胺和5-羟色胺含量。
与正常对照组相比，模型组和怒伤肝组经情绪评价量表评估的抑郁得分显著升高（P<0.01，P<0.05）；模型组得分显著高于怒伤肝组（P<0.05），经前舒颗粒治疗后恢复正常。与正常对照组相比，模型组和怒伤肝组血清单胺类神经递质水平升高（P<0.05，P<0.01），模型组血清单胺类神经递质水平显著高于怒伤肝组（P<0.05），治疗后与正常对照组比较无显著差异。
怒伤肝可致肝气郁证，且与单胺类神经递质变化有关。
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