Institute for Fertility Preservation, Department of Obstetrics and Gynecology, NY Medical College-Westchester Medical Center, Valhalla, New York 10595, USA.
Fertil Steril. 2010 Jul;94(2):753.e15-9. doi: 10.1016/j.fertnstert.2010.01.044. Epub 2010 Feb 26.
To report a novel approach to fertility preservation in adolescents with Turner syndrome mosaicism by repeated controlled ovarian stimulation and oocyte cryopreservation.
Case report.
Academic reproductive medicine center.
PATIENT(S): Fourteen-year-old adolescent diagnosed with Turner syndrome mosaicism.
INTERVENTION(S): Two cyles of controlled ovarian stimulation and oocyte cryopreservation within 1 year.
MAIN OUTCOME MEASURE(S): Recovery of oocytes after controlled ovarian stimulation and oocyte cryopreservation.
RESULT(S): Eleven oocytes were retrieved, of which eight were mature and three were immature during the first cycle. One year later, four mature and three immature oocytes were retrieved after a treatment cycle with even higher gonadotropin doses. All oocytes were cryopreserved by vitrification.
CONCLUSION(S): Controlled ovarian stimulation and oocyte cryopreservation may be an option for fertility preservation in selected adolescents with Turner syndrome mosaicism and impending ovarian failure.
报告一种通过反复控制性卵巢刺激和卵母细胞冷冻保存来为 Turner 综合征嵌合体青少年进行生育力保存的新方法。
病例报告。
学术生殖医学中心。
诊断为 Turner 综合征嵌合体的 14 岁青少年。
1 年内进行 2 个控制性卵巢刺激和卵母细胞冷冻保存周期。
控制性卵巢刺激和卵母细胞冷冻保存后卵母细胞的恢复情况。
第一个周期中，共取出 11 个卵母细胞，其中 8 个成熟，3 个不成熟。一年后，在使用更高剂量促性腺激素的治疗周期中，又取出 4 个成熟和 3 个不成熟的卵母细胞。所有卵母细胞均通过玻璃化冷冻保存。
控制性卵巢刺激和卵母细胞冷冻保存可能是 Turner 综合征嵌合体且即将发生卵巢功能衰竭的青少年进行生育力保存的一种选择。
