呼吸道合胞病毒融合受体：并非如众人所期望的那样。

The RSV fusion receptor: not what everyone expected it to be.

作者信息

Mastrangelo Peter, Hegele Richard G

机构信息

Dept. of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.

出版信息

Microbes Infect. 2012 Nov;14(13):1205-10. doi: 10.1016/j.micinf.2012.07.015. Epub 2012 Jul 31.

DOI:10.1016/j.micinf.2012.07.015

PMID:22884716

Abstract

This article reviews current knowledge about respiratory syncytial virus (RSV) binding and entry into cells. The recent discovery of Nucleolin as a fusion receptor for RSV opens new avenues for developing interventions, while raising questions concerning RSV pathobiology and tropism. We also discuss characteristics of a good RSV drug target.

摘要

本文综述了目前关于呼吸道合胞病毒（RSV）与细胞结合及进入细胞的相关知识。最近发现核仁素作为RSV的融合受体，为开发干预措施开辟了新途径，同时也引发了有关RSV发病机制和嗜性的问题。我们还讨论了理想的RSV药物靶点的特征。