Wang Zeng-feng, Feng Yuan-yong, Liu Shi-en, Li Wei, Wan Sheng-biao, Xu Wen-jian, Jiang Tao, Shang Wei
Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Medical College, Qingdao University, Shandong Province, China.
Shanghai Kou Qiang Yi Xue. 2012 Jun;21(3):283-6.
To explore the application value of the cervical lymphatic imaging in interstitial magnetic resonance lymphography using submucosal injection of Dextran-DTPA-Gd.
0.2 mL Dextran-DTPA-Gd (3.96 mmol/L) was injected into the submucosa of the bilateral lingual margins in 12 New Zealand rabbits,and then massaged the injection site for 30 seconds. MR images were obtained before injection and 10, 15, 20, 25, 30, 35, 40, 50, 90 minutes after injection by 3D TOF CE-MRA sequence.The signal intensities of cervical lymph node were measured, the enhancing rates(E%) were calculated and the signal enhancing rates -time curve was drawn. The data was analysed using SPSS11.5 software package.
The cervical lymph nodes,the first and second lymphatics were strengthened significantly after injecting Dextran-DTPA-Gd, but the blood vessels were not enhanced at the same time. The enhancing rates of cervical lymph node reached the peak(344%) at 30-min,and the best strengthening effect was achieved between 20-min and 50-min.
As IMRLG contrast agent,the Dextran-DTPA-Gd could image lymphatic drainage lines of the neck and the cervical lymph nodes efficiently.
探讨黏膜下注射葡聚糖 - 二乙三胺五乙酸钆（Dextran - DTPA - Gd）在颈部淋巴成像间质磁共振淋巴造影中的应用价值。
对12只新西兰兔双侧舌缘黏膜下注射0.2 mL Dextran - DTPA - Gd（3.96 mmol/L），然后对注射部位按摩30秒。在注射前及注射后10、15、20、25、30、35、40、50、90分钟，采用三维时间飞跃对比增强磁共振血管造影（3D TOF CE - MRA）序列获取磁共振图像。测量颈部淋巴结的信号强度，计算增强率（E%），绘制信号增强率 - 时间曲线。使用SPSS11.5软件包对数据进行分析。
注射Dextran - DTPA - Gd后，颈部淋巴结、一级和二级淋巴管明显强化，但血管同时未强化。颈部淋巴结增强率在30分钟时达到峰值（344%），在20分钟至50分钟之间达到最佳强化效果。
作为间质磁共振淋巴造影对比剂，Dextran - DTPA - Gd能够有效地显示颈部淋巴引流途径及颈部淋巴结。
