[右旋糖酐-二乙三胺五乙酸钆在舌间质磁共振淋巴造影中颈部淋巴成像的实验研究]

[An experimental study of the cervical lymphatic imaging in interstitial magnetic resonance lymphography of tongue using Dextran-DTPA-Gd].

作者信息

Wang Zeng-feng, Feng Yuan-yong, Liu Shi-en, Li Wei, Wan Sheng-biao, Xu Wen-jian, Jiang Tao, Shang Wei

机构信息

Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Medical College, Qingdao University, Shandong Province, China.

出版信息

Shanghai Kou Qiang Yi Xue. 2012 Jun;21(3):283-6.

PMID:22885488

Abstract

PURPOSE

To explore the application value of the cervical lymphatic imaging in interstitial magnetic resonance lymphography using submucosal injection of Dextran-DTPA-Gd.

METHODS

0.2 mL Dextran-DTPA-Gd (3.96 mmol/L) was injected into the submucosa of the bilateral lingual margins in 12 New Zealand rabbits,and then massaged the injection site for 30 seconds. MR images were obtained before injection and 10, 15, 20, 25, 30, 35, 40, 50, 90 minutes after injection by 3D TOF CE-MRA sequence.The signal intensities of cervical lymph node were measured, the enhancing rates(E%) were calculated and the signal enhancing rates -time curve was drawn. The data was analysed using SPSS11.5 software package.

RESULTS

The cervical lymph nodes,the first and second lymphatics were strengthened significantly after injecting Dextran-DTPA-Gd, but the blood vessels were not enhanced at the same time. The enhancing rates of cervical lymph node reached the peak(344%) at 30-min,and the best strengthening effect was achieved between 20-min and 50-min.

CONCLUSIONS

As IMRLG contrast agent,the Dextran-DTPA-Gd could image lymphatic drainage lines of the neck and the cervical lymph nodes efficiently.

摘要

目的

探讨黏膜下注射葡聚糖 - 二乙三胺五乙酸钆（Dextran - DTPA - Gd）在颈部淋巴成像间质磁共振淋巴造影中的应用价值。

方法

对12只新西兰兔双侧舌缘黏膜下注射0.2 mL Dextran - DTPA - Gd（3.96 mmol/L），然后对注射部位按摩30秒。在注射前及注射后10、15、20、25、30、35、40、50、90分钟，采用三维时间飞跃对比增强磁共振血管造影（3D TOF CE - MRA）序列获取磁共振图像。测量颈部淋巴结的信号强度，计算增强率（E%），绘制信号增强率 - 时间曲线。使用SPSS11.5软件包对数据进行分析。