心脏磁共振评估腺苷负荷下心功能和血流的正常反应。

Normal response of cardiac flow and function to adenosine stress as assessed by cardiac MR.

机构信息

Department of Radiology of the University Hospital Basel, Basel, Switzerland.

出版信息

J Cardiovasc Med (Hagerstown). 2012 Nov;13(11):720-6. doi: 10.2459/JCM.0b013e32835771c3.

DOI:10.2459/JCM.0b013e32835771c3

PMID:22885534

Abstract

AIMS

To establish the response of cardiac flow and function to adenosine stress using phase-contrast magnetic resonance (pcMR) and cine steady-state free precession (SSFP) cardiac magnetic resonance (CMR).

METHODS

Healthy volunteers (n = 10) were scanned on 1.5T at rest and under adenosine stress utilizing short-axis SSFP sequences and pcMR of the aorta and pulmonary trunk.

RESULTS

Adenosine-induced increase in heart rate was 62.7% (P < 0.001). Left and right-ventricular stroke volumes (SVs) increased by 12.2% (P = 0.048) and 11.9% (P = 0.044), left-ventricular ejection fraction by 11.8% (P = 0.002), and left-ventricular and right-ventricular cardiac output (CO) by 81.0% (P < 0.001) and 81.8% (P = 0.005). Average flow velocities in the ascending aorta and pulmonary trunk increased by 77.3% (P < 0.001) and 73.6% (P < 0.001), and peak flow velocities in the ascending aorta and pulmonary trunk by 27.2% (P < 0.001) and 22.4% (P = 0.003). End-systolic volumes in the left ventricle (LV) and right ventricle (RV) decreased by 16.4% (P = 0.020) and 19.2% (P = 0.028). Planimetric cine SSFP and pcMR-derived SV showed an excellent correlation.

CONCLUSION

In healthy volunteers, response to adenosine stress is characterized by an increase in heart rate, CO and SV of both ventricles. Excellent correlation is demonstrated between these increases and the increased blood flow velocities in the aorta and the pulmonary trunk. Thus, results support the use of flow measurements as an internal control of planimetric measurements of ventricular SV and CO.

摘要

目的

使用相位对比磁共振（pcMR）和电影稳态自由进动（cine SSFP）心脏磁共振（CMR）来确定腺苷应激对心脏血流和功能的反应。

方法

在 1.5T 上对 10 名健康志愿者进行静息和腺苷应激扫描，使用短轴 cine SSFP 序列和 pcMR 对主动脉和肺动脉进行成像。

结果

腺苷诱导的心率增加为 62.7%（P<0.001）。左、右心室的每搏量（SV）分别增加了 12.2%（P=0.048）和 11.9%（P=0.044），左心室射血分数增加了 11.8%（P=0.002），左、右心室心输出量（CO）分别增加了 81.0%（P<0.001）和 81.8%（P=0.005）。升主动脉和肺动脉的平均血流速度分别增加了 77.3%（P<0.001）和 73.6%（P<0.001），升主动脉和肺动脉的峰值血流速度分别增加了 27.2%（P<0.001）和 22.4%（P=0.003）。左心室（LV）和右心室（RV）的收缩末期容积分别减少了 16.4%（P=0.020）和 19.2%（P=0.028）。平面电影 cine SSFP 和 pcMR 衍生的 SV 显示出极好的相关性。