Genetic Health Queensland, Royal Brisbane and Women's Hospital, Brisbane, Australia.
Prenat Diagn. 2012 Nov;32(11):1049-52. doi: 10.1002/pd.3953. Epub 2012 Aug 8.
Prenatal diagnosis of a chromosomal abnormality currently involves the use of an invasive procedure, which has a risk of fetal loss. The aim of this study was to identify whether pregnancies conceived via assisted reproductive technologies were more or less likely to be subjected to an invasive procedure compared with pregnancies that were conceived spontaneously.
Population data were collated from three private ultrasound clinics across southeast Queensland, Australia.
Of the 15,032 spontaneously conceived pregnancies, 775 (5.2%) had invasive testing, while 95 (6.0%) of the 1581 pregnancies conceived through assisted reproductive technologies had invasive testing. When the uptake of testing is adjusted by the maternal age the assisted reproductive population was significantly less likely to pursue invasive testing (p = 0.003). Similarly when adjusted for the combined first trimester screen risk estimate, the assisted reproduction population is significantly less likely to undergo invasive testing than the spontaneous population (p = 0.005).
Pregnancies conceived using assisted reproductive technologies are significantly less likely to be subjected to invasive testing than pregnancies conceived spontaneously in women of the same age and combined first trimester screen risk.
目前，产前诊断染色体异常需要采用一种有胎儿丢失风险的侵入性操作。本研究旨在明确与自然妊娠相比，辅助生殖技术妊娠接受侵入性操作的可能性更高还是更低。
从澳大利亚昆士兰州东南部的三家私人超声诊所收集了人群数据。
在 15032 例自然妊娠中，775 例（5.2%）接受了侵入性检查，而 1581 例辅助生殖技术妊娠中，有 95 例（6.0%）接受了侵入性检查。当按母亲年龄调整检测率时，辅助生殖组接受侵入性检查的可能性显著降低（p=0.003）。同样，当按联合早孕期筛查风险估计值调整时，辅助生殖组接受侵入性检查的可能性也显著低于自然妊娠组（p=0.005）。
与相同年龄和联合早孕期筛查风险的自然妊娠相比，辅助生殖技术妊娠接受侵入性检查的可能性显著降低。
