磷酸酶触发的融合脂质体用于细胞不可渗透化合物的细胞质递送。
Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds.
机构信息
University of California, Berkeley, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143-0912, USA.
出版信息
Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9047-51. doi: 10.1002/anie.201204198. Epub 2012 Aug 6.
Abstract
License to fuse! A phosphorylated fusion peptide can mediate membrane fusion when the phosphates (green triangles, see scheme) are removed by phosphatases (blue spheres), delivering the contents of the liposome into the cytosol. This phosphatase-triggered approach may be useful to create target-specific lipid nanocarriers.
摘要
融合许可！当磷酸基团（绿色三角形，见方案）被磷酸酶（蓝色球体）去除时，带磷酸基团的融合肽可以介导膜融合，从而将脂质体的内容物递送到细胞质中。这种由磷酸酶触发的方法可能有助于创建靶向特定的脂质纳米载体。
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