Rüther W, Hotze A, Möller F, Bockisch A, Heitzmann P, Biersack H J
Orthopedic Department, University of Bonn, Federal Republic of Germany.
Arch Orthop Trauma Surg. 1990;110(1):26-32. doi: 10.1007/BF00431362.
Fifty-five patients with 60 suspected infections of bones or joints were studied with 99mTc-hexamethylpropyleneaminooxine- (HMPAO-) labelled leucocytes and 99mTc-labelled antigranulocyte antibodies, in part supplemented with 99mTc-labelled nanocolloid. The findings using the different procedures were in good agreement. Apart from in vertebral lesions, a negative scan--even if the radionuclide bone scan is positive--excludes an infection with high probability (sensitivity 94%). The low specificity (57%) is due to positive imaging of various non-infected lesions. Spondylitis usually shows as non-specific cold lesions. A subtraction technique with computer assisted analysis of HMPAO and nanocolloid scans provides a more precise diagnosis of this condition.
对55例疑似有60处骨或关节感染的患者，采用99m锝-六甲基丙烯胺肟（HMPAO）标记的白细胞和99m锝标记的抗粒细胞抗体进行研究，部分病例辅以99m锝标记的纳米胶体。采用不同方法的研究结果吻合度良好。除椎体病变外，即使放射性核素骨扫描呈阳性，但扫描结果为阴性时，极有可能排除感染（敏感性94%）。特异性低（57%）是由于各种非感染性病变呈阳性显像。脊柱炎通常表现为非特异性冷区病变。采用计算机辅助分析HMPAO和纳米胶体扫描的减影技术可对这种情况作出更精确的诊断。
