Schauwecker D S, Park H M, Mock B H, Burt R W, Kernick C B, Ruoff A C, Sinn H J, Wellman H N
J Nucl Med. 1984 Aug;25(8):849-53.
Studies with gallium-67 and three-phase bone imaging (TPBS), though very sensitive, are not very specific in evaluating suspected osteomyelitis (OM) that is superimposed upon other diseases causing increased bone turnover. A total of 57 patients with suspected OM were studied; this included 48 with increased bone turnover. All of the patients were studied with granulocytes labeled with In-111 acetylacetone (In-111 GRAN), TPBS and 29 of these patients had Ga-67 studies as well. In-111 GRAN had a sensitivity of 100% in acute OM and 60% in chronic OM, with a specificity of 96%. Gallium-67 was excellent in ruling out OM when the study was normal, or in ruling in OM when the relative uptake of Ga-67 exceeded the uptake of Tc-99m MDP, or when the Ga-67 in bone had a different distribution from the TPBS. Unfortunately, these criteria were met in only 28% of our subjects. We conclude that when added to TPBS, the In-111 GRAN study plays an important role in detecting complicating OM.
镓-67和三相骨显像（TPBS）研究虽然非常敏感，但在评估叠加于其他导致骨转换增加的疾病之上的疑似骨髓炎（OM）时，特异性并不高。共对57例疑似OM患者进行了研究；其中包括48例骨转换增加的患者。所有患者均接受了用铟-111乙酰丙酮标记的粒细胞（铟-111 GRAN）检查、TPBS检查，其中29例患者还进行了镓-67检查。铟-111 GRAN在急性OM中的敏感性为100%，在慢性OM中的敏感性为60%，特异性为96%。当镓-67检查结果正常时，其在排除OM方面表现出色；当镓-67的相对摄取量超过锝-99m亚甲基二膦酸盐（Tc-99m MDP）的摄取量，或者当骨内镓-67的分布与TPBS不同时，其在确诊OM方面表现出色。不幸的是，我们的研究对象中只有28%符合这些标准。我们得出结论，在TPBS基础上增加铟-111 GRAN检查，在检测并发OM方面发挥着重要作用。
