Reynolds J H, Graham D, Smith F W
Department of Diagnostic Radiology, Aberdeen Royal Infirmary, Foresterhill, Scotland.
Clin Radiol. 1990 Sep;42(3):195-8. doi: 10.1016/s0009-9260(05)81933-6.
Labelling leucocytes with 99Tcm using hexamethylpropyleneamine oxime (HMPAO) utilizes the advantages of technetium over indium in imaging inflammation. A retrospective study has been performed on 43 consecutive patients imaged with 99Tcm HMPAO labelled leucocytes in order to assess the reliability of the technique. Particular attention was paid to the different handling characteristics of the 99Tcm HMPAO labelled cells compared with those labelled with indium. It was found that 99Tcm HMPAO labelled leucocytes gave an overall accuracy of 93.2%, a sensitivity of 92.8%, a specificity of 93.3% and a positive predictive value of 86%. 99Tcm HMPAO labelled leucocyte scanning provides a reliable method of imaging inflammation, though errors in interpretation may occur due to the hepato-biliary excretion of activity that occurs with this technique.
使用六甲基丙烯胺肟（HMPAO）用99锝标记白细胞，利用了锝在炎症成像方面优于铟的优势。对43例连续使用99锝HMPAO标记白细胞成像的患者进行了一项回顾性研究，以评估该技术的可靠性。特别关注了99锝HMPAO标记细胞与铟标记细胞不同的处理特性。结果发现，99锝HMPAO标记白细胞的总体准确率为93.2%，敏感性为92.8%，特异性为93.3%，阳性预测值为86%。99锝HMPAO标记白细胞扫描提供了一种可靠的炎症成像方法，尽管由于该技术中出现的放射性药物肝胆排泄，可能会出现解释错误。
