Department of Emergency and Critical Care Medicine, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Evid Based Complement Alternat Med. 2012;2012:837958. doi: 10.1155/2012/837958. Epub 2012 Jul 24.
Jidabokuippo is a traditional Japanese medicine used for contusion-induced swelling and pain. This open multicenter randomized study was designed to compare the efficacies of jidabokuippo and nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with rib fracture by analyzing the treatment duration. Our study involved 170 rib fracture patients capable of oral ingestion divided randomly into 2 groups: the jidabokuippo and NSAID groups. We compared the duration of treatment and healthcare expenditure between these 2 groups. Medication was continued in both groups until the visual analogue scale score decreased to less than 50% of the pretreatment score. We excluded the patients in whom medication was prematurely discontinued. We analyzed 81 patients belonging to the jidabokuippo and NSAIDs groups. No significant intergroup differences were observed in age, gender, severity (injury severity score), and presence/absence of underlying disease. The treatment duration was significantly shorter in the jidabokuippo group than in the NSAIDs group (P = 0.0003). Healthcare expenditure was significantly lower in the jidabokuippo group than in the NSAIDs group (P < 0.0001). Our results suggest that compared to NSAIDs, jidabokuippo can shorten the duration of treatment in patients with rib fracture and is a promising analgesic agent based on the medical economic viewpoint.
跌打宝是一种传统的日本药物，用于治疗挫伤引起的肿胀和疼痛。本开放性多中心随机研究旨在通过分析治疗持续时间，比较跌打宝和非甾体抗炎药 (NSAIDs) 在肋骨骨折患者中的疗效。我们的研究纳入了 170 名能够口服药物的肋骨骨折患者，将他们随机分为 2 组：跌打宝组和 NSAIDs 组。我们比较了这两组的治疗持续时间和医疗支出。两组患者均继续用药，直至视觉模拟评分 (VAS) 降至治疗前评分的 50%以下。我们排除了提前停药的患者。我们分析了 81 名属于跌打宝和 NSAIDs 组的患者。两组在年龄、性别、严重程度 (损伤严重程度评分) 和是否存在基础疾病方面无显著差异。跌打宝组的治疗持续时间明显短于 NSAIDs 组 (P = 0.0003)。跌打宝组的医疗支出明显低于 NSAIDs 组 (P < 0.0001)。我们的结果表明，与 NSAIDs 相比，跌打宝可缩短肋骨骨折患者的治疗持续时间，从医疗经济角度来看，是一种有前途的镇痛药物。
