Carlei F, Carotenuto F, Manzi R, Dorsi E, Gatti C, Sciarratta F, Mariani P, Roberti R, Pietroletti R, Natellis C
Anatomia Chirurgica e Corso di Operazioni, Università degli Studi de L'Aquila.
G Chir. 1990 Sep;11(9):475-9.
In this study the authors have investigated the different morphofunctional features of the gallbladder mucosa in patients with uncomplicated cholelithiasis. Histological changes, type and distribution of endocrine and mucin-producing cells were characterized by immunocytochemistry and mucin histochemistry. The authors attempted to correlate these findings to the number and size of gallbladder stones as well as type of bacteria present in the bile. The results indicate that, despite similar clinical parameters, a wide range of histological changes may occur in the gallbladder mucosa of these patients. Moreover, the presence of some endocrine and mucin-producing cell types in the so called "pyloric metaplasia" led the Authors to hypothesize that the latter may be a trivial event.
在本研究中，作者调查了无并发症胆结石患者胆囊黏膜的不同形态功能特征。通过免疫细胞化学和黏蛋白组织化学对组织学变化、内分泌细胞和黏蛋白产生细胞的类型及分布进行了表征。作者试图将这些发现与胆结石的数量和大小以及胆汁中存在的细菌类型相关联。结果表明，尽管临床参数相似，但这些患者的胆囊黏膜可能会出现广泛的组织学变化。此外，在所谓的“幽门化生”中存在一些内分泌细胞和黏蛋白产生细胞类型，这使得作者推测后者可能是一个微不足道的事件。
