Laitio M
Pathol Res Pract. 1980;167(2-4):335-45. doi: 10.1016/S0344-0338(80)80063-X.
One hundred and three gallbladders were excised from 81 female and 22 male patients. Different non-tumorous morphologic and histochemical changes and their frequency were studied in these gallbladders and in their various components. Histochemical methods were used to visualize sulphated, non-sulphated acid, and neutral mucins. Sulphated mucin predominated in normal columnar epithelium and in the glands of the neck region, whereas non-sulphated acid mucin and neutral mucin predominated in goblet cell areas, in superficial gastric-type epithelial areas and in antral-type glands. Goblet cells were present in 67 specimens, enterochromaffin cells in 42, superficial gastric-type epithelium in 16, antral-type glands in 40, antral-type mucosa in 8 and intestinal-type mucosa in one specimen. Goblet cells, enterochromaffin cells, and gastric surface epithelium columns appeared initially in the surface portions of the folds. No relationship was established between the degree of metaplasia, the age of the patient, the duration of symptons, and the severity of illness.
从81名女性和22名男性患者身上切除了103个胆囊。对这些胆囊及其各个组成部分的不同非肿瘤性形态学和组织化学变化及其频率进行了研究。采用组织化学方法观察硫酸化、非硫酸化酸性和中性黏蛋白。硫酸化黏蛋白在正常柱状上皮和颈部区域的腺体中占主导地位，而非硫酸化酸性黏蛋白和中性黏蛋白在杯状细胞区域、浅表胃型上皮区域和胃窦型腺体中占主导地位。67个标本中存在杯状细胞，42个中有肠嗜铬细胞，16个中有浅表胃型上皮，40个中有胃窦型腺体，8个中有胃窦型黏膜，1个标本中有肠型黏膜。杯状细胞、肠嗜铬细胞和胃表面上皮柱最初出现在皱襞的表面部分。化生程度、患者年龄、症状持续时间和疾病严重程度之间未建立关联。
