Nephrology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Ren Fail. 2012;34(9):1109-13. doi: 10.3109/0886022X.2012.713280. Epub 2012 Aug 14.
The relative importance of inflammatory markers in relation with metabolic syndrome (MeS) in hemodialysis (HD) patients is uncertain. This study investigated the association between MeS and high-sensitive C-reactive protein (hsCRP), hallmark of inflammation, and other inflammatory-related biomarkers. The study included 153 patients who were dialyzed at least for the last 3 months. The serum level of hsCRP was assessed by high-sensitive Enzyme-linked immunosorbent assay (ELISA). MeS was defined using the modified National Cholesterol Education Program Adult Treatment Panel III (ATP-III). Ninety-one HD patients (59.5%) were diagnosed as having MeS. Lower level of high-density lipoprotein-cholesterol (HDL-C) was the most prevalent MeS component (85.6%). The serum level of hsCRP in these patients was significantly higher than that in HD patients without MeS (2.3 ± 1.7 vs. 1.7 ± 1.6 mg/dL, p = 0.03). A significant linear increase in the hsCRP levels was found according to the number of MeS components (β = 0.09, p = 0.022). The study concluded that increasing inflammatory biomarkers, especially hsCRP, is associated with MeS in HD patients.
在血液透析 (HD) 患者中，炎症标志物与代谢综合征 (MeS) 的关系的相对重要性尚不确定。本研究调查了 MeS 与高敏 C 反应蛋白 (hsCRP)（炎症的标志）和其他炎症相关生物标志物之间的关系。该研究纳入了至少接受了 3 个月透析的 153 名患者。采用高敏酶联免疫吸附试验 (ELISA) 检测 hsCRP 血清水平。使用改良的美国国家胆固醇教育计划成人治疗专家组 III (ATP-III) 定义 MeS。91 名 HD 患者（59.5%）被诊断为患有 MeS。高密度脂蛋白胆固醇 (HDL-C) 水平较低是最常见的 MeS 成分（85.6%）。这些患者的 hsCRP 血清水平明显高于无 MeS 的 HD 患者（2.3±1.7 比 1.7±1.6 mg/dL，p=0.03）。根据 MeS 成分的数量，hsCRP 水平呈显著线性增加（β=0.09，p=0.022）。研究结论认为，炎症生物标志物（尤其是 hsCRP）的增加与 HD 患者的 MeS 有关。
