University of Zagreb School of Medicine, University Hospital Merkur, Zagreb, Croatia.
J Hematol Oncol. 2012 Aug 13;5:50. doi: 10.1186/1756-8722-5-50.
Graft versus host disease (GVHD) is an uncommon complication after orthotopic liver transplantation (OLT) with an incidence of 0.1-2%, but an 80-100% mortality rate. Patients can present with skin rashes, diarrhea, and bone marrow aplasia between two to eight weeks after OLT. Diagnosis of GVHD is made based on clinical and histologic evidence, supported by chimerism studies showing donor HLA alleles in the recipient bone marrow or blood. Several therapeutic approaches have been used for the management of GVHD after OLT including increased immunosuppression, decreased immunosuppression, and cellular therapies. However, success rates have been low, and new approaches are needed.
移植物抗宿主病（GVHD）是肝移植（OLT）后一种罕见的并发症，发病率为 0.1-2%，但死亡率为 80-100%。患者可在 OLT 后 2-8 周出现皮疹、腹泻和骨髓再生障碍。GVHD 的诊断基于临床和组织学证据，并通过嵌合体研究支持，该研究显示供体 HLA 等位基因在受者骨髓或血液中。OLT 后 GVHD 的治疗方法包括增加免疫抑制、减少免疫抑制和细胞治疗等。然而，成功率一直较低，需要新的方法。
