Department of Disease Control and Epidemiology, National Veterinary Institute, SE-751 89 Uppsala, Sweden.
Transbound Emerg Dis. 2013 Oct;60(5):438-47. doi: 10.1111/j.1865-1682.2012.01364.x. Epub 2012 Aug 13.
Sweden experienced its first outbreak of bluetongue virus (BTV) infection beginning in September 2008. Mandatory vaccination with an inactivated vaccine (BTVPUR Alsap8; Merial, Lyon, France) began 2 days after bluetongue was confirmed in the country. The aim of this study was to investigate whether the goal of 80% seroconversion by the susceptible population within the vaccination area was met during the initial phase of the Swedish vaccination campaign and whether there were discrepancies between subpopulations. Milk or blood samples were collected from 274 cattle randomly selected from the vaccinated population. Blood samples were also collected from ten ewes on each of 28 randomly selected vaccinated herds. The vaccination campaign in Sweden may be regarded as successful, as measured by apparent seroprevalence in the vaccinated population. The overall apparent seroprevalence was 77%, and in cattle, which constituted the majority of the susceptible population, the apparent seroprevalence was 82%. Factors that influenced the titres after vaccination were as follows: (i) the time span between vaccination and sampling and (ii) the age of the animals.
瑞典于 2008 年 9 月首次暴发蓝舌病病毒（BTV）感染。在该国确诊蓝舌病后 2 天，开始对易感人群进行 BTVPUR Alsap8（梅里亚，里昂，法国）灭活疫苗的强制性免疫接种。本研究旨在调查在瑞典疫苗接种活动的初始阶段，是否达到了接种区域内易感人群 80%血清转化率的目标，以及是否存在亚群差异。从接种人群中随机选择了 274 头奶牛采集奶样或血样。还从 28 个随机选择的接种牛群中每群采集了 10 只母羊的血样。根据接种人群的明显血清阳性率，瑞典的疫苗接种活动可以被视为成功的。总体明显血清阳性率为 77%，在构成大部分易感人群的牛中，血清阳性率为 82%。接种后影响效价的因素有：（i）接种和采样之间的时间间隔，（ii）动物的年龄。
