新诊断的亚临床甲状腺功能减退症患者的心外膜脂肪组织增加。
Epicardial adipose tissue increased in patients with newly diagnosed subclinical hypothyroidism.
机构信息
Department of Cardiology, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, Trabzon, Turkey.
出版信息
Med Princ Pract. 2013;22(1):42-6. doi: 10.1159/000340065. Epub 2012 Aug 9.
OBJECTIVE
To investigate whether or not patients with subclinical hypothyroidism (SH) have increased epicardial adipose tissue (EAT).
SUBJECTS AND METHODS
Sixty-one patients with newly diagnosed SH and without any known cardiovascular disease were enrolled. Twenty-four subjects matched for age, gender and body mass index without any thyroid dysfunctions were included as a control group. The EAT was measured by echocardiography and thyroid functions were assessed by routine blood examination.
RESULTS
Patients with SH had higher EAT values than control subjects (3.6 ± 0.9 vs. 2.8 ± 1.4, p = 0.005). Also, SH patients with thyroid-stimulating hormone (TSH) ≥10 mU/l had higher EAT than those with SH with TSH <10 mU/l and control subjects (p = 0.013). In addition, while there was significant correlation between EAT and TSH (r = 0.31, p = 0.014) in patients with SH, there was no significant relation between EAT and TSH in normal subjects (r = 0.09, p = 0.64).
CONCLUSIONS
There was a higher level of EAT in patients with SH compared with normal subjects and a significant correlation between EAT and TSH was found.
目的
研究亚临床甲状腺功能减退症（SH）患者是否存在心外膜脂肪组织（EAT）增加。
对象与方法
共纳入 61 例新诊断的 SH 患者，且无任何已知心血管疾病。24 例年龄、性别和体重指数匹配，无任何甲状腺功能障碍的患者作为对照组。通过超声心动图测量 EAT，通过常规血液检查评估甲状腺功能。
结果
与对照组相比，SH 患者的 EAT 值更高（3.6 ± 0.9 比 2.8 ± 1.4，p = 0.005）。此外，SH 患者中 TSH≥10 mU/l 的患者 EAT 高于 TSH<10 mU/l 的 SH 患者和对照组（p = 0.013）。此外，在 SH 患者中，EAT 与 TSH 之间存在显著相关性（r = 0.31，p = 0.014），而在正常受试者中，EAT 与 TSH 之间无显著相关性（r = 0.09，p = 0.64）。
结论
与正常受试者相比，SH 患者的 EAT 水平更高，且 EAT 与 TSH 之间存在显著相关性。
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