亚临床甲状腺功能减退患者的心外膜脂肪组织

Epicardial adipose tissue in patients with subclinical hypothyroidism.

作者信息

Unubol M, Eryilmaz U, Guney E, Akgullu C, Kurt Omurlu I

机构信息

Division of Endocrinology Department of Internal Medicine Adnan Menderes University Medical Faculty Aydin, Turkey -

出版信息

Minerva Endocrinol. 2014 Jun;39(2):135-40.

PMID:24736488

Abstract

AIM

There remains conflicting opinions regarding the relationship between the risk of cardiovascular disease and subclinical hypothyroidism (SH), and there are also varying study results. Recent growing evidence suggests that epicardial adipose tissue (EAT) may play a key role in the pathogenesis and development of coronary artery disease. The effects of SH on echocardiographic EAT is not currently known. The aim of this present study was to measure echocardiographic EAT with anthropometric and clinical parameters in patients with SH.

METHODS

The study was designed as a prospective and case-controlled study. Body fat ratio, echocardiographic EAT measurements, body mass index, and the waist circumference of patients were measured for analysis.

RESULTS

Epicardial adipose tissue was measured to be 3.83±1.04 mm for patients with SH, while it was measured to be 2.81±0.74 mm in the control group, and there was a significant difference detected between two groups (P<0.001).

CONCLUSION

In the present study significantly increased EAT in patients with SH was detected.

摘要

目的

关于心血管疾病风险与亚临床甲状腺功能减退（SH）之间的关系仍存在相互矛盾的观点，研究结果也各不相同。最近越来越多的证据表明，心外膜脂肪组织（EAT）可能在冠状动脉疾病的发病机制和发展中起关键作用。目前尚不清楚SH对超声心动图测量的EAT有何影响。本研究的目的是在SH患者中测量超声心动图EAT，并分析其与人体测量学和临床参数的关系。