冷激活棕色脂肪组织是女性更高骨密度的独立预测因子。
Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women.
机构信息
Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg 10, CRC, 10 Center Drive, Bethesda, MD, USA.
出版信息
Osteoporos Int. 2013 Apr;24(4):1513-8. doi: 10.1007/s00198-012-2110-y. Epub 2012 Aug 14.
UNLABELLED
In animals, defective brown adipogenesis leads to bone loss. Whether brown adipose tissue (BAT) mass relates to bone mineral density (BMD) in humans is unclear. We determined the relationship between BAT mass and BMD by cold-stimulated positron-emission tomography (PET) and dual-energy X-ray absorptiometry (DXA) in healthy volunteers. Higher BAT mass was associated with higher BMD in healthy women, but not in men, independent of age and body composition.
INTRODUCTION
Contrary to the traditional belief that BAT is present only in infants, recent studies revealed significant depots of BAT present in adult humans. In animals, defective brown adipogenesis leads to bone loss. While white adipose tissue mass is a known determinant of BMD in humans, the relationship between BAT and BMD in humans is unclear. We thus examined the relationship between BAT and BMD in healthy adults.
METHODS
BAT volume (ml) and activity (standard uptake value) were determined by 18F-fluorodeoxyglucose PET after overnight mild cold exposure at 19 °C, and BMD was determined by DXA.
RESULTS
Among 24 healthy adults (age 28±1 years, F=10), BAT volumes were 82.4±99.5 ml in women and 49.7±54.5 ml in men. Women manifested significantly higher BAT activity, by 9.4±8.1% (p=0.03), than men. BAT volume correlated positively with total and spine BMD (r2=0.40 and 0.49, respectively, p<0.02) in women and remained a significant predictor after adjustment for age, fat, and lean body mass (p<0.05). Total and spine BMD were higher in women who harbored visually detectable BAT on PET images than those without by 11±2% (p=0.02) and 22±2% (p<0.01), respectively. No associations were observed between BAT parameters and BMD in men.
CONCLUSIONS
This study demonstrated higher BMD among healthy women with more abundant BAT, independent of age and other body compositional parameters. This was not observed in men. The data suggest that brown adipogenesis may be physiologically related to modulation of bone density.
未加标签
在动物中，棕色脂肪生成缺陷会导致骨丢失。在人类中，棕色脂肪组织（BAT）的质量是否与骨矿物质密度（BMD）有关尚不清楚。我们通过健康志愿者的冷刺激正电子发射断层扫描（PET）和双能 X 射线吸收法（DXA）确定了 BAT 质量与 BMD 之间的关系。在健康女性中，BAT 质量较高与 BMD 较高相关，但在男性中则不然，这与年龄和身体成分无关。
引言
与传统观念相反，即 BAT 仅存在于婴儿中，最近的研究表明，成年人体内存在大量的 BAT。在动物中，棕色脂肪生成缺陷会导致骨丢失。虽然白色脂肪组织质量是人类 BMD 的已知决定因素，但 BAT 与人类 BMD 之间的关系尚不清楚。因此，我们检查了健康成年人中 BAT 与 BMD 之间的关系。
方法
在 19°C 的夜间轻度寒冷暴露后，通过 18F-氟脱氧葡萄糖 PET 测定 BAT 体积（ml）和活性（标准摄取值），并通过 DXA 测定 BMD。
结果
在 24 名健康成年人（年龄 28±1 岁，F=10）中，女性的 BAT 体积为 82.4±99.5ml，男性为 49.7±54.5ml。女性的 BAT 活性明显更高，为 9.4±8.1%（p=0.03）。女性的 BAT 体积与总骨密度和脊柱骨密度呈正相关（r2=0.40 和 0.49，分别，p<0.02），并且在调整年龄、脂肪和瘦体重后仍然是一个显著的预测因素（p<0.05）。在 PET 图像上具有可检测到的 BAT 的女性的总骨密度和脊柱骨密度比没有 BAT 的女性分别高 11±2%（p=0.02）和 22±2%（p<0.01）。在男性中，BAT 参数与 BMD 之间没有观察到关联。
结论
本研究表明，健康女性中 BAT 较多的 BMD 较高，独立于年龄和其他身体成分参数。在男性中则不然。这些数据表明，棕色脂肪生成可能与调节骨密度有关。
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