Kara Necip, Yildirim Yusuf, Univar Tolga, Kontbay Tugba
Department of Ophthalmology, Kanuni Sultan Suleyman Education and Research Hospital, Istanbul - Turkey.
Eur J Ophthalmol. 2013 Jan 21;23(1):27 - 32. doi: 10.5301/ejo.5000196. Epub 2012 Aug 7.
Purpose. To compare the biomechanical properties of corneas in eyes of children with diabetes mellitus and in eyes of children without diabetes mellitus. Methods. In this prospective, comparative, and cross-sectional study, 46 patients with diabetes mellitus (study group) and 50 healthy individuals (control group) were enrolled. The corneal hysteresis (CH) and corneal resistance factor (CRF) were measured in children with and without diabetes using the Ocular Response Analyzer. Differences in the corneal biomechanical properties were determined using an independent-samples t test. Correlations between ocular and diabetic parameters were also evaluated. Results. Mean CH was 12.3±1.3 (SD) mmHg and 12.5±1.5 mmHg and the mean CRF was 12.4±1.7 mmHg and 11.9±1.5 mmHg in the diabetic and control groups, respectively (p>0.05). Corneal hysteresis and CRF were not correlated with fasting glucose level, HbA1c, age, or duration of diabetes. Conclusions. The findings indicate that diabetes mellitus does not affect corneal biomechanical parameters such as CH and CRF in children. In addition, CH and CRF are not affected by fasting glucose level, HbA1c, age, or duration of diabetes.
目的。比较糖尿病患儿与非糖尿病患儿眼角膜的生物力学特性。
方法。在这项前瞻性、对比性横断面研究中,纳入了46例糖尿病患者(研究组)和50名健康个体(对照组)。使用眼反应分析仪测量糖尿病患儿和非糖尿病患儿的角膜滞后值(CH)和角膜阻力因子(CRF)。采用独立样本t检验确定角膜生物力学特性的差异。还评估了眼部参数与糖尿病参数之间的相关性。
结果。糖尿病组和对照组的平均CH分别为12.3±1.3(标准差)mmHg和12.5±1.5 mmHg,平均CRF分别为12.4±1.7 mmHg和11.9±1.5 mmHg(p>0.05)。角膜滞后值和CRF与空腹血糖水平、糖化血红蛋白、年龄或糖尿病病程均无相关性。
结论。研究结果表明,糖尿病不影响儿童角膜的生物力学参数,如CH和CRF。此外,CH和CRF不受空腹血糖水平、糖化血红蛋白、年龄或糖尿病病程的影响。