P450 复合物 I 催化脂肪酸氧化的速率与 pH 值有关。
Rates of fatty acid oxidations by P450 compound I are pH dependent.
机构信息
Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor St., Chicago, IL 60607, USA.
出版信息
Chembiochem. 2012 Sep 24;13(14):2061-4. doi: 10.1002/cbic.201200387. Epub 2012 Aug 13.
Abstract
The rates of oxidation of fatty acids by CYP119 compound I were dependent on the pH of the medium. The plot shows log k values for reactions of acids as a function of pH, where the slopes indicate mixed third-order and fourth-order dependence on base concentration. For palmitic acid, the rate increased 50-fold over the pH range 6.8-7.3.
摘要
CYP119 化合物 I 氧化脂肪酸的速率取决于介质的 pH 值。该图显示了作为 pH 函数的酸反应的 log k 值，其中斜率表明对碱浓度的混合三阶和四阶依赖性。对于棕榈酸，在 pH 值 6.8-7.3 的范围内，速率增加了 50 倍。
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