头孢菌素-3'-二氮烯二醇盐：用于分散细菌生物膜的靶向 NO 供体前药。
Cephalosporin-3'-diazeniumdiolates: targeted NO-donor prodrugs for dispersing bacterial biofilms.
机构信息
School of Biotechnology and Biomolecular Sciences and Centre for Marine Bio-Innovation, University of New South Wales, New South Wales, Australia.
出版信息
Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9057-60. doi: 10.1002/anie.201202414. Epub 2012 Aug 13.
PMID:22890975
Abstract
Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication.
摘要
对生物膜说“不”：NO-供体用于分散细菌生物膜，以便共同给予的抗生素能够杀死更易受影响的游离细胞。化学稳定的头孢菌素-3'-二氮烯二酸盐 NO-供体前药被细菌β-内酰胺酶激活，并促进这两步生物膜消除。
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