Wang Tian-Yu, Zhu Xiao-Yu, Wu Fu-Gen
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing, 210096, PR China.
Bioact Mater. 2022 Nov 11;23:129-155. doi: 10.1016/j.bioactmat.2022.10.008. eCollection 2023 May.
One of the challenges posed by current antibacterial therapy is that the expanded and massive use of antibiotics endows bacteria with the ability to resist almost all kinds of antibiotics. Therefore, developing alternative strategies for efficient antibacterial treatment is urgently needed. Antibacterial gas therapy has attracted much attention in the past decade. Nitric oxide (NO), carbon monoxide (CO), sulfur dioxide (SO), hydrogen sulfide (HS), and hydrogen (H) are not only known as endogenous signaling molecules, but also play critical roles in many pathological processes. These gases are considered as attractive bactericidal agents because they are able to kill bacteria, disperse biofilms, and promote bacteria-infected wound healing while avoiding resistance. In this review, we discuss the bactericidal properties of these gases, as well as the recent advances of gas-involving systems in antibacterial, antibiofilm, and wound treatment applications. Moreover, we summarize various gas donors utilized in antibacterial treatment. We hope this review will shed new light on the future design and applications of advanced antibacterial gas therapy.
当前抗菌治疗面临的挑战之一是抗生素的广泛大量使用使细菌具备了抵抗几乎所有种类抗生素的能力。因此，迫切需要开发高效抗菌治疗的替代策略。在过去十年中，抗菌气体疗法备受关注。一氧化氮（NO）、一氧化碳（CO）、二氧化硫（SO）、硫化氢（HS）和氢气（H）不仅被视为内源性信号分子，而且在许多病理过程中发挥着关键作用。这些气体被认为是有吸引力的杀菌剂，因为它们能够杀死细菌、分散生物膜并促进细菌感染伤口的愈合，同时避免耐药性。在本综述中，我们讨论了这些气体的杀菌特性，以及气体参与系统在抗菌、抗生物膜和伤口治疗应用方面的最新进展。此外，我们总结了抗菌治疗中使用的各种气体供体。我们希望本综述将为先进抗菌气体疗法的未来设计和应用提供新的思路。
